Betahistine in the treatment of tinnitus in patients with vestibular disorders

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dc.contributor.authorGanança, Mauricio Malavasi [UNIFESP]
dc.contributor.authorCaovilla, Heloisa Helena [UNIFESP]
dc.contributor.authorGazzola, Juliana Maria
dc.contributor.authorGananca, Cristina Freitas [UNIFESP]
dc.contributor.authorGanança, Fernando Freitas [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Bandeirante Sao Paulo
dc.date.accessioned2018-06-15T16:24:05Z
dc.date.available2018-06-15T16:24:05Z
dc.date.issued2011-07-01
dc.description.abstractBetahistine is a medicine used to treat vestibular disorders that has also been used to treat tinnitus.Aim: To assess the effects of betahistine on tinnitus in patients with vestibular disorders.Material and method: Retrospective data were collected from patient records for individuals presenting with vestibular dysfunction and tinnitus. Patients included had received betahistine 48 mg/day and clinical outcomes were compared with a control group comprising individuals who were unable to receive betahistine due to gastritis, ulcers, pregnancy, asthma or hypersensitivity to the drug. Patients underwent control of any aggravating factors and also standard vestibular exercises as a basis for treatment. The intensity, frequency and duration of tinnitus were assessed on the first day of dosing and after 120 days of treatment. Clinical improvement was defined as a total or partial reduction of tinnitus after treatment.Results: Clinical improvement was observed in 80/262 (30.5%) of patients treated with betahistine and 43/252 (17.1%) of control patients. Betahistine significantly (p<0.0001) improved tinnitus in treated individuals.Conclusion: The daily dosage of 48 mg of betahistine during 120 consecutive days is useful to reduce or eliminate tinnitus in patients with vestibular disorders.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Paulista Sch Med EPM, Sao Paulo, Brazil
dc.description.affiliationUniv Bandeirante Sao Paulo, Program Body Balance Rehabil & Social Inclus, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Otol & Neurotol Program, Paulista Sch Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Speech & Hearing Therapy, Paulista Sch Med, Human Commun Disorders Grad Program, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Otol & Neurotol Program, UNIFESP EPM, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Paulista Sch Med EPM, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Otol & Neurotol Program, Paulista Sch Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Speech & Hearing Therapy, Paulista Sch Med, Human Commun Disorders Grad Program, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Otol & Neurotol Program, UNIFESP EPM, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent499-503
dc.identifierhttp://dx.doi.org/10.1590/S1808-86942011000400014
dc.identifier.citationBrazilian Journal Of Otorhinolaryngology. Sao Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 77, n. 4, p. 499-503, 2011.
dc.identifier.doi10.1590/S1808-86942011000400014
dc.identifier.fileS1808-86942011000400014-en.pdf
dc.identifier.fileS1808-86942011000400014-pt.pdf
dc.identifier.issn1808-8694
dc.identifier.scieloS1808-86942011000400014
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43153
dc.identifier.wosWOS:000293863600014
dc.language.isoeng
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.relation.ispartofBrazilian Journal Of Otorhinolaryngology
dc.rightsAcesso aberto
dc.subjectdizzinessen
dc.subjectmedication therapyen
dc.subjectmanagementen
dc.subjecttinnitusen
dc.subjectvertigoen
dc.titleBetahistine in the treatment of tinnitus in patients with vestibular disordersen
dc.title.alternativeBetaistina no tratamento do zumbido em pacientes com distúrbios vestibularespt
dc.typeArtigo
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