Sleep-related movement disorder symptoms in SHR are attenuated by physical exercise and an angiotensin-converting enzyme inhibitor

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dc.citation.volume154
dc.contributor.authorFrank, Miriam Kannebley
dc.contributor.authorMello, Marco Tulio de
dc.contributor.authorLee, Kil Sun [UNIFESP]
dc.contributor.authorDaubian-Nose, Paulo
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorEsteves, Andrea Maculano
dc.coverageOxford
dc.date.accessioned2020-10-30T18:46:29Z
dc.date.available2020-10-30T18:46:29Z
dc.date.issued2016
dc.description.abstractThe relationship between hypertension and sleep-related movement disorders has been hypothesized for humans, but the causes and mechanisms have not been elucidated. We investigated whether an alteration in blood pressure (BP) induced by physical exercise and/or an angiotensin-converting enzyme inhibitor (enalapril) could affect locomotor activity in spontaneously hypertensive rats, with emphasis on the dopaminergic system. We used SHR and normotensive Wistar rats distributed into 4 groups for each strain: control, physical exercise, enalapril and physical exercise + enalapril. Physical exercise was performed on a treadmill, and enalapril was administered by gavage, both for 8 weeks. During this period, locomotor activity was evaluated in an open field test, and BP was evaluated by tail plethysmography. Dopaminergic receptors, dopamine transporter and tyrosine hydroxylase levels at the striatum were evaluated by Western blotting. The control group of spontaneously hypertensive rats showed higher BP, increased activity in the open field test and lower levels of D2 receptors and tyrosine hydroxylase compared with all other groups throughout the experimental period. In general, physical exercise and enalapril attenuated these alterations. This study suggested the existence of comorbidity between hypertension and sleep-related movement disorders in spontaneously hypertensive rats. Physical exercise and enalapril conferred protection for both hypertension and the observed behavioral changes. In addition, these treatments led to changes in dopaminergic signaling in the striatal region (i.e., D2 receptor, TH and DAT). (C) 2015 Elsevier Inc All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Fac Ciencias Aplicadas, Limeira, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Esportes, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Bioquim, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Bioquim, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipAssociação Fundo de Incentivo a Pesquisa
dc.description.sponsorshipIDFAPESP: 2011/21729-3
dc.description.sponsorshipIDFAPESP: 2013/22413-5
dc.format.extent161-168
dc.identifierhttps://doi.org/10.1016/j.physbeh.2015.11.026
dc.identifier.citationPhysiology & Behavior. Oxford, v. 154, p. 161-168, 2016.
dc.identifier.doi10.1016/j.physbeh.2015.11.026
dc.identifier.issn0031-9384
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58479
dc.identifier.wosWOS:000369207000021
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPhysiology & Behavior
dc.rightsAcesso restrito
dc.subjectSpontaneously hypertensive ratsen
dc.subjectRestless legs syndromeen
dc.subjectPhysical exerciseen
dc.subjectEnalaprilen
dc.subjectDopamineen
dc.titleSleep-related movement disorder symptoms in SHR are attenuated by physical exercise and an angiotensin-converting enzyme inhibitoren
dc.typeArtigo
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