Microbioma e doenças do trato respiratório
Date
2022-02-04
Authors
Egami, Felipe Yukio [UNIFESP]
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Lopes, Patricia Santos [UNIFESP]
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Trabalho de conclusão de curso de graduação
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Abstract
O sistema respiratório está diariamente exposto a agressores químicos e microbiológicos que podem desequilibrar a homeostasia. Devido as diversas doenças do trato respiratório e o surgimento do novo coronavírus, vírus responsável por causar a doença COVID-19, novas moléculas, vacinas e terapias estão sendo estudadas para combater o vírus e as doenças respiratórias. O eixo intestino-pulmão, um dos campos de estudo em potencial devido ao Projeto Microbioma Humano, recebeu maior atenção pela relação da disbiose e diversas doenças como câncer, obesidade, Alzheimer e inclusive em pacientes com COVID-19. Em virtude da pandemia do novo coronavírus, desde sua descoberta em dezembro de 2019, e pelo progresso do desenvolvimento de vacinas e protocolos de tratamentos, o presente trabalho apresenta o papel do microbioma intestinal e o uso de probióticos como estratégia terapêutica complementar para evitar a progressão de doenças do trato respiratório. Foram pesquisados artigos em bases cientificas como, Google Acadêmico, Web of Science, PubMed assim como livros oferecido pela biblioteca virtual da UNIFESP que possuíam em seu conteúdo o assunto buscado. A metodologia adotada para busca foram artigos e livros publicados entre os anos de 2007 e 2021 em idiomas em português, e inglês. Conclui-se que compreender as relações das alterações dos microrganismos do intestino-pulmão e a comunicação entre esses dois órgãos podem contribuir no desenvolvimento de novas terapias envolvendo a modulação do eixo intestino-pulmão através do uso de probióticos.
The respiratory system is daily exposed to chemical and microbiological aggressors that can unbalance homeostasis. Several respiratory tract diseases and due the emergence of the new coronavirus, the virus responsible for causing COVID-19 disease, new molecules, vaccines and therapies are being studied to fight the virus and respiratory diseases. The gut-lung axis, one of the potential fields of study due to the Human Microbiome Project, increased attention due to the relationship between dysbiosis and several diseases such as cancer, obesity, Alzheimer's and even in patients with COVID-19. Due to the new coronavrus pandemic, since its discovery in December 2019, and the progress in the development of vaccines and treatment protocols, this paper presents the role of the intestinal microbiome and the use of probiotics as a complementary therapy strategy to prevent progression of respiratory tract diseases. Articles in scientific databases such as Google Scholar, Web of Science, PubMed were searched, as well as books offered by the virtual library of UNIFESP that had in their content the searched subject. The methodology adopted for the search was articles and books published between 2007 and 2021 in Portuguese and English. It is concluded that understanding the relationships of changes in gut-lung microorganisms and the communication between these two organs can contribute to the development of new therapies involving the modulation of the gut-lung axis through the use of probiotics.
The respiratory system is daily exposed to chemical and microbiological aggressors that can unbalance homeostasis. Several respiratory tract diseases and due the emergence of the new coronavirus, the virus responsible for causing COVID-19 disease, new molecules, vaccines and therapies are being studied to fight the virus and respiratory diseases. The gut-lung axis, one of the potential fields of study due to the Human Microbiome Project, increased attention due to the relationship between dysbiosis and several diseases such as cancer, obesity, Alzheimer's and even in patients with COVID-19. Due to the new coronavrus pandemic, since its discovery in December 2019, and the progress in the development of vaccines and treatment protocols, this paper presents the role of the intestinal microbiome and the use of probiotics as a complementary therapy strategy to prevent progression of respiratory tract diseases. Articles in scientific databases such as Google Scholar, Web of Science, PubMed were searched, as well as books offered by the virtual library of UNIFESP that had in their content the searched subject. The methodology adopted for the search was articles and books published between 2007 and 2021 in Portuguese and English. It is concluded that understanding the relationships of changes in gut-lung microorganisms and the communication between these two organs can contribute to the development of new therapies involving the modulation of the gut-lung axis through the use of probiotics.