Furazolidone-based triple therapy for H pylori gastritis in children
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2006-09-14
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Kawakami, Elisabete [UNIFESP]
Machado, Rodrigo Strehl [UNIFESP]
Ogata, Silvio Kazuo [UNIFESP]
Langner, Marini [UNIFESP]
Fukushima, Erika [UNIFESP]
Carelli, Anna Paula [UNIFESP]
Bonucci, Vania Claudia Guimaraes [UNIFESP]
Patricio, Francy Reis Silva [UNIFESP]
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AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms sufficiently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive C-13-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and C-13-urea breath test. Further clinical evaluation was performed 7 cl, 2 and 6 mo after the treatment.RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 +/- 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI,. 78.5%-91%)., All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate efficacy in H pylori treatment. The eradication rate seems to be higher in patients with duodenal ulcer. (C) 2006 The WJG Press. All rights reserved.
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World Journal Of Gastroenterology. Beijing: W J G Press, v. 12, n. 34, p. 5544-5549, 2006.