Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine
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2008-07-01
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Calzavara, Mariana Bendlin [UNIFESP]
Andersen, Monica Levy [UNIFESP]
Fukushiro, Daniela Fukue [UNIFESP]
Lopez, Giorgia Batlle [UNIFESP]
Abilio, Vanessa Costhek [UNIFESP]
Tufik, Sergio [UNIFESP]
Frussa-Filho, Roberto [UNIFESP]
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We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. in the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied on AMPH-induced behavioural sensitization. Sleep rebound attenuated the acute locomotor-stimulating effect of AMPH. AMPH-induced behavioural sensitization was context-specific and was also attenuated by sleep rebound. These results strengthen the notion that sleep conditions can influence AMPH-incluced behavioural sensitization. (C) 2008 Elsevier Inc. All rights reserved.
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Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 32, n. 5, p. 1277-1282, 2008.