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- ItemAnti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)(Sociedade Brasileira de Química, 2012-01-01) Santos, Roberta Tancredi dos [UNIFESP]; Hiramoto, Liliane Lumi [UNIFESP]; Lago, Joao Henrique Ghilardi [UNIFESP]; Sartorelli, Patricia [UNIFESP]; Tempone, André Gustavo [UNIFESP]; Pinto, Erika Gracielle; Universidade Federal de São Paulo (UNIFESP); Instituto Adolfo Lutz Departamento de Parasitologia; Universidade de São Paulo (USP); Instituto Plantarum de Estudos da FloraMeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.