EPM - Artigos
Recent Submissions
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Comparative phenotypic and genomic features of Staphylococci from sonication fluid of orthopedic implant-associated infections with poor outcome
(MDPI, 2022-06-02)Staphylococcus spp. remain the leading biofilm-forming agents causing orthopedic im-plant-associated infections (OIAI). This is a descriptive study of phenotypic and genomic features identified in clinical isolates of S. ...
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Cell-surface glycosaminoglycans regulate the cellular uptake of charged polystyrene nanoparticles
(Chunli Bai, 2022-05-02)Engineered nanoparticles approaching the cell body will first encounter and interact with cell-surface glycosaminoglycans (GAGs) before reaching the plasma membrane and becoming internalized. However, how surface GAGs may ...
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Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring
(Michele R. Brumley, 2020-03)Stress during gestation has been shown to affect susceptibility and intensity of seizures in offspring. Environmental stimuli, such as maternal physical exercise, have shown to be beneficial for brain development. Although ...
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Validity and item response theory properties of the Patient Health Questionnaire-9 for primary care depression screening in Mozambique (PHQ-9-MZ)
(BMC Psychiatry, 2020)Background: Depression is one of the leading causes of disability in Mozambique; however, few patients with depression are identified in primary care. To our knowledge, there are no validated tools for depression screening ...
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Mitochondrial sirtuin TcSir2rp3 affects TcSODA activity and oxidative stress response in Trypanosoma cruzi
(Frontiers, 2021)Trypanosoma cruzi faces a variety of environmental scenarios during its life cycle, which include changes in the redox environment that requires a !ne regulation of a complex antioxidant arsenal of enzymes. Reversible ...
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Trypanosoma cruzi
(Cell Press, 2021)Trypanosoma cruzi is the etiological agent of American trypanosomiasis, or Chagas disease, and is transmitted mainly by blood-sucking reduviid insects in endemic countries. Metacyclic trypomastigotes released in the feces ...
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Protein acetylation in the critical biological processes in protozoan parasites
(Cell Press, 2021)Protein lysine acetylation has emerged as a major regulatory post-translational modi!cation in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone ...
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Epitranscriptome machinery in Trypanosomatids: new players on the table?
(Wiley, 2021)Trypanosoma and Leishmania parasites cause devastating tropical diseases resulting in serious global health consequences. These organisms have complex life cycles with mammalian hosts and insect vectors. The parasites must, ...
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Use of LeishGEdit CRISPR-Cas9 technology for genetic manipulation of protozoan parasite Leishmania
(JoVE, 2021)The cell biology of a parasitic protozoan as well as the impact of the infection in host cells can be addressed using genome modification techniques. The development of robust methods eases the burden to obtain gene mutants ...
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Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity
(Portland Press, 2020)Post-translational modifications provide suitable mechanisms for cellular adaptation to environmental changes. Lysine acetylation is one of these modifications and occurs with the addition of an acetyl group to Nε-amino ...
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Chemogenetic characterization of inositol phosphate metabolic pathway reveals druggable enzymes for targeting kinetoplastid parasites
(Cell Press, 2016)Kinetoplastids cause Chagas disease, human Afri- can trypanosomiasis, and leishmaniases. Current treatments for these diseases are toxic and ineffi- cient, and our limited knowledge of drug targets and inhibitors has ...
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Preclinical gold complexes as oral drug candidates to treat leishmaniasis are potent Trypanothione reductase inhibitors
(ACS Publications, 2020)The drugs currently used to treat leishmaniases have limitations concerning cost, e!cacy, and safety, making the search for new therapeutic approaches urgent. We found that the gold(I)-derived complexes were active against ...
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Characterization of Trypanosoma cruzi Sirtuins as possible drug targets for Chagas disease
(ASM, 2015)Acetylation of lysine is a major posttranslational modification of proteins and is catalyzed by lysine acetyltransferases, while lysine deacetylases remove acetyl groups. Among the deacetylases, the sirtuins are NAD(+)-dependent ...
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Panacea within a Pandora's box: the antiparasitic effects of phospholipases A2 (PLA2s) from snake venoms
(Cell Press, 2021)Parasitic diseases affect millions of individuals worldwide, mainly in low-income regions. There is no cure for most of these diseases, and the treatment relies on drugs that have side effects and lead to drug resistance, ...
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Raising the Bar(-seq) in Leishmania genetic screens
(Cell Press, 2021)Our understanding of regulatory factors in Leishmania differentia- tion has long been restricted by the available genetic tools, but the availability of CRISPR/Cas9 has changed the landscape forever. Recently, Baker and ...
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Chromatin proteomics reveals variable histone modifications during the life cycle of Trypanosoma cruzi
(ACS Publications, 2016)Histones are well-conserved proteins that form the basic structure of chromatin in eukaryotes and undergo several post-translational modifications, which are important for the control of transcription, replication, DNA ...
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Lysine acetylation as drug target in fungi: an underexplored potential in Aspergillus spp.
(SBM, 2020)In recent years, the intensification of the use of immunosuppressive therapies has increased the incidence of invasive infections caused by opportunistic fungi. Considering that, the spread of azole resistance and amphotericin ...
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Identification of inhibitors to Trypanosoma cruzi Sirtuins based on compounds developed to human enzymes
(MDPI, 2020)Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi, a↵ecting more than 7 million people in the world. Benznidazole and nifurtimox are the only drugs available for treatment and in addition to ...
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Chemical constituents of Anacardium occidentale as inhibitors of Trypanosoma cruzi Sirtuins
(MDPI, 2019)Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse side effects. Thus, there is an urgent need to find new biotargets ...
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The current drug discovery landscape for trypanosomiasis and leishmaniasis: challenges and strategies to identify drug targets
(Willey Periodicals, 2020)Human trypanosomiasis and leishmaniasis are vector-borne neglected tropical diseases caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp., respectively. Once restricted to endemic areas, ...
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