EPM - Artigos

 

Recent Submissions

  • How would a completely homogeneous malignant hyperthermia susceptible sample be? 

    Silva, Helga Cristina Almeida da [UNIFESP]; Andrade, Pamela Vieira de [UNIFESP]; Valim, Lívia Maria [UNIFESP]; Santos, Joilson Moura [UNIFESP]; Castro, Isac de [UNIFESP]; Amaral, Jose Luiz Gomes do [UNIFESP] (SBA, 2023-10-21)
    Dear Editor, We read with interest the letter to the editor by Finsterer et al.1 We appreciated the interest in our article2 and the comments, which gave us the opportunity to include additional data from our research and ...

  • Rabies virus variants from bats closely related to variants found in marmosets (Callithrix jacchus), a neglected source of human rabies infection in Brazil 

    de Sousa, Larissa Leão Ferrer [UNIFESP]; de Souza, Tatiane Lira [UNIFESP]; Tibo, Luiz Henrique Soares [UNIFESP]; Moura, Francisco Bergson Pinheiro; Soares Júnior, Francisco Atualpa; Oliveira-Filho, Edmilson Ferreira de; Ludwig-Begall, Louisa; de Miranda, Gustavo Cabral; Santos, Robert Andreata [UNIFESP]; Janini, Luiz Mário Ramos [UNIFESP]; Poon, Leo; Durães-Carvalho, Ricardo [UNIFESP] (Shou-Jiang Gao, 2023-08-22)
    Rabies is a fatal viral zoonosis caused by rabies virus (RABV). RABV infects the central nervous system and triggers acute encephalomyelitis in both humans and animals. Endemic in the Brazilian Northeast region, RABV ...

  • Food addiction and grazing - The role of difficulties in emotion regulation and negative urgency in university students 

    Ribeiro, Andreia; Sinval, Jorge [UNIFESP]; Félix, Sílvia; Guimarães, Carolina; Machado, Bárbara César; Gonçalves, Sónia; de Lourdes, Marta; Conceição, Eva M. (MDPI, 2023-10-17)
    University students are a vulnerable population to the development of disordered eating, such as food addiction (FA) and grazing. FA is an emerging concept characterized by an intense desire to eat hyper-palatable foods. ...

  • Rhabdomyosarcoma Associated with Core Myopathy/Malignant Hyperthermia: Combined Effect of Germline Variants in RYR1 and ASPSCR1 May Play a Role 

    Silva, Helga Cristina Almeida da [UNIFESP]; Andrade, Pâmela Vieira de [UNIFESP]; Santos, Joilson Moura dos [UNIFESP]; Teixeira, Anne Caroline Barbosa; Sogari, Vanessa Fante [UNIFESP]; Almeida, Michelle Samora de [UNIFESP]; Callegari, Fabiano Mesquita [UNIFESP]; Krepischi, Ana Cristina Victorino; Oliveira, Acary Souza Bulle [UNIFESP]; Vainzof, Mariz (MDPI, 2023-06-27)
    Rhabdomyosarcomas have been described in association with thyroid disease, dermatomyositis, Duchenne muscular dystrophy, and in muscular dystrophy models but not in patients with ryanodine receptor-1 gene (RYR1) pathogenic ...

  • Association between mental disorders and adherence to antiretroviral treatment in health facilities in two Mozambican provinces in 2018: a cross-sectional study 

    Mandlate, Flavio Machado [UNIFESP]; Greene, M. Claire; Pereira, Luis F.; Gouveia,Maria Lidia [UNIFESP]; Mari, Jair Jesus [UNIFESP]; Cournos, Francine; Duarte, Cristiane S.; Oquendo, Maria A.; Mello, Marcelo Feijó [UNIFESP]; Wainberg, Milton L. (Anao Zhang, 2023-04-20)
    Introduction: Lower adherence to antiretroviral treatment (ART) has been found among people with HIV (PWH) who have comorbid mental disorders like depression and alcohol use in Sub-Saharan African. However, there has been ...

  • Lay HIV counselors' knowledge and attitudes toward depression: a mixed-methods cross-sectional study at primary healthcare centers in Mozambique 

    Mandlate, Flavio Machado [UNIFESP]; Greene, M. Claire; Pereira, Luis F.; Sweetland, Annika C.; Kokonya, Donald; Duarte, Cristiane S.; Cournos, Francine; Oquendo, Maria A.; Wainberg, Milton L.; Sidat, Mohsin ,; Sevene, Esperança; Mello, Marcelo F. [UNIFESP] (Aliya Naheed, 2022-09-28)
    Introduction: Depression is the most common mental disorder among people living with HIV/AIDS and has a negative impact on HIV treatment outcomes. Training lay HIV counselors to identify and manage depression may contribute ...

  • A biophysical study of DNA condensation mediated by histones and protamines 

    da Silva, Emerson Rodrigo [UNIFESP]; Souza, Bruna B.S. [UNIFESP]; Lourenço, Thiago C. [UNIFESP]; Gerbelli, Barbara B.; Oseliero Filho, Pedro L.; Oliveira, Cristiano L.P. [UNIFESP]; Miranda, Antonio [UNIFESP] (Elsivier, 2022-12-15)
    The compaction of long DNA strands into confined spaces such as the nuclei of eukaryotic cells is an essential phenomenon towards the emergence of elaborated forms of life. Histones and protamines are the major nucleoproteins ...

  • Aggregation limiting cell-penetrating peptides derived from protein signal sequences 

    da Silva, Emerson Rodrigo [UNIFESP]; Bicev, Renata Naporano [UNIFESP]; Porosk, Ly; Härk, Heleri; Armolik, Eger-Jasper; Langel, Ülo; Nebogatova, Jekaterina; Gaidutsik, Ilja; Arukuust, Piret (MDPI, 2023-02-16)
    Alzheimer’s disease (AD) is the most common neurodegenerative disease (ND) and the leading cause of dementia. It is characterized by non-linear, genetic-driven pathophysiological dynamics with high heterogeneity in the ...

  • Modification of the linker amino acid in the cell-penetrating peptide NickFect55 leads to enhanced pDNA transfection for in vivo applications 

    Porosk, Ly; Mello, Lucas; da Silva, Emerson Rodrigo [UNIFESP]; Härk, Heleri; Kurrikoff, Kaido; Arukuust, Piret (MDPI, 2023-02-20)
    Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors. ...

  • Structure optimization of lipopeptide assemblies for aldol reactions in an aqueous medium 

    da Silva, Emerson Rodrigo [UNIFESP]; Soares, Bruna Miranda; Sodré, Pedro; Arguello, Karina; Aguilar, Andrea; Pelin, Juliane; Gerbelli, Barbara Bianca; Schmuck, Carsten; Farias, Marcelo; Portugal, Rodrigo; Coutinho-Neto, Maurício; Alves, Wendel Andrade (Royal Society of Chemistry, 2021-03-09)
    Four amphiphilic peptides were synthesized, characterized, and evaluated regarding their efficiency in the catalysis of direct aldol reactions in water. The lipopeptides differ by having a double lipid chain and a guanidinium ...

  • Amyloid formation by short peptides in the presence of dipalmitoylphosphatidylcholine membranes 

    da Silva, Emerson Rodrigo [UNIFESP]; Gerbelli, Barbara Bianca; Alves, Wendel Andrade; Oliveira, Cristiano Luis Pinto; Hamley, Ian (American Chemical Society, 2020-11-19)
    The aggregation of two short peptides [RF] and [RF]4 (where R = arginine and F = phenylalanine) with dipalmitoylphosphatidylcholine (DPPC) model membranes was investigated at the air-water interface using the Langmuir ...

  • Nanostructure formation and cell spheroid morphogenesis of a peptide supramolecular hydrogel 

    da Silva, Emerson [UNIFESP]; Mello, Lucas R. [UNIFESP]; Carrascosa, Vinicius [UNIFESP]; Oliveira, Eduardo R. L. [UNIFESP]; Juliano, Maria A. [UNIFESP]; Hamley, Ian W.; Castelletto, Valeria; Vassiliades, Sandra V.; Alves, Wendel A.; Nakaie, Clovis R. [UNIFESP] (American Chemical Society, 2022-03-11)
    Peptide-based hydrogels have attracted much attention due to their extraordinary applications in biomedicine and offer an excellent mimic for the 3D microenvironment of the extracellular matrix. These hydrated matrices ...

  • Time evolution of ultrasmall gold nanoparticle−protein interactions 

    Sousa, Alioscka Augusto [UNIFESP]; Lima, André Ferreira [UNIFESP]; Guido, Vinicius Silva [UNIFESP]; Mina, Natasha [UNIFESP]; Torquato, Ricardo José Soares [UNIFESP] (Gilbert Walker, 2023-05-02)
    To date, much effort has been devoted toward the study of protein corona formation onto large gold nanoparticles (GNPs). However, the protein corona concept breaks down for GNPs in the ultrasmall size regime (<3 nm), and, ...

  • ZnO nanoparticle/poly(vinyl alcohol) nanocomposites via 2 microwave-assisted sol−gel synthesis for structural materials, UV 3 shielding, and antimicrobial activity 

    da Silva, Emerson Rodrigo [UNIFESP]; Factori, Irina Marinho; Amaral, Júlia Maia do; Camani, Paulo Henrique; Rosa, Derval dos Santos; Lima, Bruna A.; Brocchi, Marcelo; Souza, Juliana dos Santos de (American Chemical Society, 2021-06-09)
    Polymer nanocomposites based on poly(vinyl alcohol) (PVA) and ZnO hold a privileged position in the development of organic/inorganic hybrid multifunctional materials for applications ranging from food packing to biotechnological ...

  • Amyloid-like self-assembly of a hydrophobic cell-penetrating peptide and its use as a carrier for nucleic acids 

    da Silva, Emerson Rodrigo [UNIFESP]; Mello, Lucas Rodrigues de [UNIFESP]; Porosk, Ly; Lourenço, Thiago da Costa [UNIFESP]; Garcia, Bianca Bonetto Moreno [UNIFESP]; Costa, Carlos Alberto Rodrigues; Han, Sang Won [UNIFESP]; Souza, Juliana dos Santos de; Langel, Ülo (American Chemical Society, 2021-08-04)
    Cell-penetrating peptides (CPPs) are a topic subject potentially exploitable for creating new nanotherapeutics for the delivery of bioactive loads. These compounds are often classified into three major categories according ...

  • Molecular structure and antibacterialactivity of degradation products from cephalexin solutions submitted to thermal and photolytic stress 

    da Silva, Emerson Rodrigo [UNIFESP]; Valêncio, André [UNIFESP]; Machado, Marcelo Ferreira Marcondes [UNIFESP]; Miranda, Antonio [UNIFESP] (Willey, 2022-11-21)
    Cephalexin is a beta-lactam antibiotic of the first generation of cephalosporins which is very effective against various bacterial infections. In this work, we investigate the structure and antibacterial activity of ...

  • Respiratory epithelial cells: more than just a physical barrier to fungal infections 

    Barros, Bianca Carla Silva Campitelli; Almeida, Bruna Rocha; Barros, Débora Tereza Lucas [UNIFESP]; Toledo, Marcos Sergio [UNIFESP]; Suzuki, Erika [UNIFESP] (MDPI, 2022-05-24)
    The respiratory epithelium is highly complex, and its composition varies along the conducting airways and alveoli. In addition to their primary function in maintaining the respiratory barrier and lung homeostasis for gas ...

  • Paracoccidioides brasiliensis downmodulates α3 integrin levels in human lung epithelial cells in a TLR2-dependent manner 

    Barros, Bianca Carla Silva Campitelli; Almeida, Bruna Rocha; Suzuki, Erika [UNIFESP] (Nature, 2020-11-10)
    Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America and may be caused by the species Paracoccidioides brasiliensis. In the lungs, this fungus interacts with epithelial cells, activating ...

  • Impact of a digital manual for guidance on malignant hyperthermia: patient education 

    Rodrigues, Gislene [UNIFESP]; Andrade, Pamela Vieira de [UNIFESP]; Santos, Joilson Moura dos [UNIFESP]; Amaral. José Luiz Gomes do [UNIFESP]; Silva, Helga Cristina Almeida da [UNIFESP] (BMC, 2022-07)
    Background Malignant hyperthermia (MH) is a rare, hereditary disease with a hypermetabolic response to volatile anesthetics/succinylcholine. Susceptible patients face difficulties due to a lack of knowledge about MH. As ...

  • European Neuromuscular Centre consensus statement on anaesthesia in patients with neuromuscular disorders 

    Bersselaar, Luuk R. van den; Tasca, Giorgio; Silva, Helga Cristina Almeida da [UNIFESP]; Heytens, Luc; Reimann, Jens; Díaz- Cambronero, Óscar; Lokken, Nicoline; Hellblom, Anna; Hopkins, Philip M.; Rueffert, Henrik; Bastian, Börge; Vilchez, Juan Jesus; Gillies, Robyn; Stephan Johannsen; Veyckemans, Francis; Muenster, Tino; Klein, Andrea; Litman, Ron; Jungbluth, Heinz; Voermans, Nicol C.; Snoeck, Marc M. J.; Riazi, Sheila (Wiley Online Library, 2022-12)
    Background and purpose: Patients with neuromuscular conditions are at increased risk of suffering perioperative complications related to anaesthesia. There is currently little specific anaesthetic guidance concerning these ...

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