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    • 1 ano de pandemia em SP 

      Thieghi, Leila Thomazelli [UNIFESP]; Cuppo, Fabio L. S.; Medina, Matheus [UNIFESP]; Paterno, Paulo Favaretto [UNIFESP] (Universidade Federal de São Paulo, 2021-06-06)
      Resumo das internações e óbitos decorrentes das internações no estado de SP no último ano, e primeiros resultados da vacinação.

    • 1,25-dihydroxyvitamin D3 induces growth of thyroid C cells and inhibits calcitonin secretion in vitro 

      Lazaretti-Castro, Marise [UNIFESP]; Vieira, JGH; Raue, F.; Norman, A. W.; Bouillon, R.; Thomasset, M. (Walter De Gruyter, 1994-01-01)

    • 1,25-Dihydroxyvitamin D3 stimulates growth and inhibits calcitonin secretion in a human C cell carcinoma cell line 

      Lazaretti-Castro, Marise [UNIFESP]; Grauer, A.; Baier, R.; Vieira, Jose Gilberto Henriques [UNIFESP]; Ziegler, R.; Raue, F. (Assoc Bras Divulg Cientifica, 1995-09-01)
      1,25-Dihydroxyvitamin D3 (1,25D3), calcitonin (CT) and parathyroid hormone are the major calcium-regulating hormones. In addition, 1,25D3 has been reported to be a modulator of cell growth and differentiation in many ...

    • 1,4-Diamino-2-butanone, a putrescine analogue, promotes redox imbalance in Trypanosoma cruzi and mammalian cells 

      Soares, Chrislaine O; Colli, Walter; Bechara, Etelvino José Henriques [UNIFESP]; Alves, Maria Julia Manso (Elsevier B.V., 2012-12-15)
      The putrescine analogue 1,4-diamino-2-butanone (DAB) is highly toxic to various microorganisms, including Trypanosoma cruzi. Similar to other a-aminocarbonyl metabolites. DAB exhibits pro-oxidant properties. DAB undergoes ...

    • 1,4-Diamino-2-butanone, a Wide-spectrum Microbicide, Yields Reactive Species by Metal-catalyzed Oxidation 

      Soares, Chrislaine Oliveira; Manso Alves, Maria Julia; Bechara, Etelvino J. H. [UNIFESP] (Elsevier B.V., 2010-01-01)

    • 1,4-Diamino-2-butanone, a wide-spectrum microbicide, yields reactive species by metal-catalyzed oxidation 

      Soares, Chrislaine Oliveira; Alves, Maria Julia Manso; Bechara, Etelvino José Henriques [UNIFESP] (Elsevier B.V., 2011-06-15)
      The alpha-aminoketone 1,4-diamino-2-butanone (DAB), a putrescine analogue, is highly toxic to various microorganisms, including Trypanosoma cruzi. However, little is known about the molecular mechanisms underlying DAB's ...

    • 1,5-asymmetric induction in boron-mediated aldol reactions of beta-oxygenated methyl ketones 

      Dias, Luiz C.; Aguilar, Andrea M. [UNIFESP] (Royal Soc Chemistry, 2008-01-01)
      This tutorial review describes that high levels of substrate-controlled, 1,5-stereoinduction are obtained in the boron-mediated aldol reactions of beta-oxygenated methyl ketones with achiral and chiral aldehydes. Remote ...

    • 1-[(2,3-Dihydro-1-benzofuran-2-yl) methyl]piperazines as novel anti-inflammatory compounds: Synthesis and evaluation on H3R/H4R 

      Correa, Michelle Fidelis [UNIFESP]; Varela, Marina Themoteo [UNIFESP]; Balbino, Aleksandro Martins [UNIFESP]; Torrecilhas, Ana Claudia [UNIFESP]; Landgraf, Richardt Gama [UNIFESP]; Paolo Troncone, Lanfranco Ranieri; dos Santos Fernandes, Joao Paulo [UNIFESP] (Wiley, 2017)
      The histamine receptors (HRs) are members of G-protein-coupled receptor superfamily and traditional targets of huge therapeutic interests. Recently, H3R and H4R have been explored as targets for drug discovery, including ...

    • 1-[(Z)-1-Bromo-2-(butyldichloro-lambda(4)tellanyl)ethenyl]cyclohex-1-ene 

      Zukerman-Schpector, Julio; Caracelli, Ignez; Guadagnin, Rafael Carlos [UNIFESP]; Stefani, Helio A.; Tiekink, Edward R. T. (Wiley-Blackwell, 2011-07-01)
      The Te-IV atom in the title compound, [Te(C4H9)(C8H10Br)Cl-2] or C12H19BrCl2Te, is in a distorted psi-trigonal-bipyramidal geometry, with the lone pair of electrons projected to occupy a position in the equatorial plane, ...

    • [1-Sarcosine]-angiotensin II tachyphylaxis in helical strips and everted rings of rabbit aorta 

      Silva, Eneida de Gusmão [UNIFESP]; Paiva, Therezinha Bandiera [UNIFESP] (Assoc Bras Divulg Cientifica, 1989-01-01)

    • 1-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients With Severe Mitral Annular Calcification 

      Guerrero, Mayra; Urena, Marina; Himbert, Dominique; Wang, Dee Dee; Eleid, Mackram; Kodali, Susheel; George, Isaac; Chakravarty, Tarun; Mathur, Moses; Holzhey, David; Pershad, Ashish; Fang, H. Kenith; O'Hair, Daniel; Jones, Noah; Mahadevan, Vaikom S.; Dumonteil, Nicolas; Rodes-Cabau, Josep; Piazza, Nicolo; Ferrari, Enrico; Ciaburri, Daniel; Nejjari, Mohammed; DeLago, Augustin; Sorajja, Paul; Zahr, Firas; Rajagopal, Vivek; Whisenant, Brian; Shah, Pinak Bipin; Sinning, Jan-Malte; Witkowski, Adam; Eltchaninoff, Helene; Dvir, Danny; Martin, Bena; Attizzani, Guilherme F.; Gaia, Diego Felipe [UNIFESP]; Nunes, Nagela S. V.; Fassa, Amir-Ali; Kerendi, Faraz; Pavlides, Gregory; Iyer, Vijay; Kaddissi, Georges; Witzke, Christian; Wudel, James; Mishkel, Gregory; Raybuck, Bryan; Wang, Chi; Waksman, Ron; Palacios, Igor; Cribier, Alain; Webb, John; Bapat, Vinnie; Reisman, Mark; Makkar, Raj; Leon, Martin; Rihal, Charanjit; Vahanian, Alec; O'Neill, William; Feldman, Ted (Elsevier Science Inc, 2018)
      BACKGROUND The risk of surgical mitral valve replacement in patients with severe mitral annular calcification (MAC) is high. Several patients worldwide with severe MAC have been treated successfully with transcatheter ...

    • 1.70 angstrom X-ray structure of human apo kallikrein 1: Structural changes upon peptide inhibitor/substrate binding 

      Laxmikanthan, G.; Blaber, S. I.; Bernett, M. J.; Scarisbrick, I. A.; Juliano, M. A.; Blaber, M. (Wiley-Blackwell, 2005-03-01)
      Human kallikreins are serine proteases that comprise a recently identified large and closely related 15-member family. the kallikreins include both regulatory- and degradative-type proteases, impacting a variety of ...

    • Os 100 anos da insulina e novos tratamentos para o diabetes mellitus tipo 2 

      Silva, Thayna do Carmo [UNIFESP] (Universidade Federal de São Paulo, 2022-07-25)
      Dados globais e locais dão conta do aumento contínuo dos casos de Diabetes Melittus (DM) no mundo e em nosso país, que provocam gastos gigantescos, diretos e indiretos, no sentido de controlar seus efeitos. Na presente ...

    • 100% rapid rescreening for quality assurance in a quality control program in a public health cytologic laboratory 

      Ferraz, Maria da Gloria Mattosinho de Castro [UNIFESP]; Dall'Agnol, Miria [UNIFESP]; Di Loreto, Celso; Pirani, William Marques; Utagawa, Maria Lucia; Pereira, Sonia Maria Miranda; Sakai, Yuriko Ito [UNIFESP]; Feres, Camilo de Lelis; Shih, Lai Wun Song; Yamamoto, Luzia Setuko Umeda; Rodrigues, Rosemeire Oliveira Lima; Shirata, Neusa Kasumi; Longatto Filho, Adhemar (Sci Printers & Publ Inc, 2005-11-01)
      Objective To verify the efficacy of the quality control (QC) program in a cytologic laboratoiy with a rapid rescreening (PR) protocol.Study Design RR, according to the Turret RR method, of all samples initially screened ...

    • 12-month prevalence and concomitants of DSM-IV depression and anxiety disorders in two violence-prone cities in Brazil 

      Blay, Sergio Luis [UNIFESP]; Fillenbaum, Gerda G.; Mello, Marcelo Feijó de [UNIFESP]; Quintana, Maria Inês [UNIFESP]; Mari, Jair de Jesus [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Andreoli, Sergio Baxter [UNIFESP] (Elsevier Science Bv, 2018)
      Background: Estimating 12-month prevalence of depression, anxiety, and comorbid anxiety/depression in noninstitutionalized adults (age 15-75) in two violence-prone cities. Methods: The Composite International Diagnostic ...

    • A 12-wk follow-up study to evaluate the effects of mixing insulin lispro and insulin glargine in young individuals with type 1 diabetes 

      Lucchesi, Maria B. B. [UNIFESP]; Komatsu, William R. [UNIFESP]; Gabbay, Monica Andrade Lima [UNIFESP]; Dib, Sergio A. [UNIFESP] (Wiley-Blackwell, 2012-11-01)
      Objective: This study was performed to compare in real-life conditions the serum profile of insulin lispro (IL) after a subcutaneous (SC) injection, separate and mixed with insulin glargine (IG), using a sensitive ...

    • A 15-year study on the treatment of undernourished children at a nutrition rehabilitation centre (CREN), Brazil 

      Fernandes, Mariana B. F. [UNIFESP]; Lopez, Rossano V. M.; Albuquerque, Maria P. de [UNIFESP]; Marchesano, Anna C. [UNIFESP]; Clemente, Ana P. G. [UNIFESP]; Martins, Vinicius J. B. [UNIFESP]; Sawaya, Ana L. [UNIFESP] (Cambridge Univ Press, 2012-06-01)
      Objective: To build a life table and determine the factors related to the time of treatment of undernourished children at a nutrition rehabilitation centre (CREN), São Paulo, Brazil.Design: Nutritional status was assessed ...

    • 15M e novas expressões da política: Gavin Adams e Henrique Parra entrevistam Xavier Toret e Bernardo Gutiérrez 

      Toret, Xavier; Gutierrez, Bernardo; Parra, Henrique Zoqui Martins [UNIFESP]; Adams, Gavin (Programa de Pós-Graduação de Psicologia Clínica da PUC-SP, 2013)
      Após alguns dias de discussões e troca de experiências entre ativistas espanhóis e brasileiros, resolvemos gravar uma entrevista que nos ajudasse a sistematizar parte das reflexões e questões que emergiam nos debates. ...

    • 17 alpha-HYDROXYLASE DEFICIENCY IS AN UNDERDIAGNOSED DISEASE: HIGH FREQUENCY OF MISDIAGNOSES IN A LARGE COHORT OF BRAZILIAN PATIENTS 

      Fontenele, Rafaela [UNIFESP]; Costa-Santos, Marivania [UNIFESP]; Kater, Claudio E. [UNIFESP] (Amer Assoc Clinical Endocrinologists, 2018)
      Objective: 17 alpha-Hydroxylase deficiency (P450c17D) is characterized by hypogonadism and mineralocorticoid hypertension. We aimed to estimate the relative incidence and spectrum of preliminary misdiagnoses in Brazilian ...

    • 17 beta-Estradiol and steady-state concentrations of H2O2: antiapoptotic effect in endometrial cells from patients with endometriosis 

      Andrade, Sheila Siqueira [UNIFESP]; Azevedo, Aline de Cássia [UNIFESP]; Monasterio, Izabel C. G. [UNIFESP]; Paredes-Gamero, Edgar Julian [UNIFESP]; Gonçalves, Giovana Aparecida [UNIFESP]; Bonetti, Tatiana Carvalho de Souza [UNIFESP]; Albertoni, Guilherme Ambrozio [UNIFESP]; Schor, Eduardo [UNIFESP]; Barreto, Jose A.; Oliva, Maria Luiza Vilela [UNIFESP]; Juliano, Luiz [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP] (Elsevier B.V., 2013-07-01)
      Increased levels of hydrogen peroxide (H2O2) can initiate protective responses to limit or repair oxidative damage. However, H2O2 signals also fine-tune responses to growth factors and cytokines controlling cell division, ...