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Title: Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus
Authors: Vieira, Michele Juliane [UNIFESP]
Perosa, Sandra Regina [UNIFESP]
Argañaraz, Gustavo Adolfo [UNIFESP]
Silva Junior, Jose Antonio [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein Neurofisiologia Clínica
Universidade de Brasília Faculdade de Ciências da Saúde Laboratório de Patologia Molecular
Universidade Nove de Julho Departamento de Educação Física Programa de Pós-Graduação em Ciências da Reabilitação
Keywords: Indomethacin
Inflammatory Mediators
Issue Date: 1-Sep-2014
Publisher: Faculdade de Medicina / USP
Citation: Clinics. Faculdade de Medicina / USP, v. 69, n. 9, p. 621-626, 2014.
Abstract: OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules.METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry.RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin.CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.
ISSN: 1807-5932
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Appears in Collections:Artigo

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