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Title: Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease
Authors: Vendramini, Alex Augusto
Lábio, Roger Willian de
Rasmussen, Lucas Trevizani [UNIFESP]
Reis, Nathali Mattiuzo dos [UNIFESP]
Minett, Thaís Soares Cianciarullo [UNIFESP]
Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Pinhel, Marcela Augusta de Souza
Souza, Dorotéia Rossi Silva
Mazzotti, Diego Robles [UNIFESP]
Smith, Marilia de Arruda Cardoso [UNIFESP]
Payão, Spencer Luiz Marques [UNIFESP]
Universidade do Sagrado Coração
Faculdade de Medicina de Marília Hemocentro
Universidade Federal de São Paulo (UNIFESP)
Faculdade de Medicina de São José do Rio Preto
Keywords: IL-8
Alzheimer's Disease
inflammatory response
Issue Date: 1-Jan-2011
Publisher: Sociedade Brasileira de Genética
Citation: Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 34, n. 1, p. 1-5, 2011.
Abstract: An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques. Cytokines, such as interleukin-8 (IL-8) and interleukin-1α (IL-1α), have been clearly involved in this inflammatory process. Polymorphisms of several interleukin genes have been correlated to the risk of developing AD. The present study investigated the association of AD with polymorphisms IL-8 -251T > A (rs4073) and IL-1α-889C > T (rs1800587) and the interactive effect of both, adjusted by the Apolipoprotein E genotype. 199 blood samples from patients with AD, 146 healthy elderly controls and 95 healthy young controls were obtained. DNA samples were isolated from blood cells, and the PCR-RFLP method was used for genotyping. The genotype distributions of polymorphisms IL-8, IL-1α and APOE were as expected under Hardy-Weinberg equilibrium. The allele frequencies did not differ significantly among the three groups tested. As expected, the APOE4 allele was strongly associated with AD (p < 0.001). No association of AD with either the IL-1α or the IL-8 polymorphism was observed, nor was any interactive effect between both polymorphisms. These results confirm previous studies in other populations, in which polymorphisms IL-8 -251T > A and IL-1α-889C > T were not found to be risk factors for AD.
ISSN: 1415-4757
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