Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/58680
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dc.contributor.authorDinelli, Maria Isabel Saraiva [UNIFESP]
dc.contributor.authorOno, Erika [UNIFESP]
dc.contributor.authorViana, Patricia Oliveira [UNIFESP]
dc.contributor.authorSpina, Fernanda Garcia [UNIFESP]
dc.contributor.authorWeckx, Lily Yin [UNIFESP]
dc.contributor.authorNunes dos Santos, Amelia Miyashiro [UNIFESP]
dc.contributor.authorde Moraes-Pinto, Maria Isabel [UNIFESP]
dc.date.accessioned2020-11-03T14:40:41Z-
dc.date.available2020-11-03T14:40:41Z-
dc.date.issued2016
dc.identifierhttps://doi.org/10.1016/j.vaccine.2015.12.017
dc.identifier.citationVaccine. Oxford, v. 34, n. 4, p. 404-407, 2016.
dc.identifier.issn0264-410X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58680-
dc.description.abstractThe use of immunosuppressive drugs can impair vaccination responses. When used during pregnancy, they may interfere with the development of the fetus's immune system. However, little is known regarding their influence on infant's response to vaccinations. Twenty-seven children born to renal transplant mothers (Tx) taking immunosuppressive drugs and 31 healthy children had the humoral immune response and reactogenicity to tetanus, Haemophilus influenzae type b (Hib) and 7 pneumococcal serotypes evaluated. The evolution of BCG vaccine scar was also registered. Antibodies were measured by ELISA. Lymphocyte immunophenotyping was performed on cord blood and at 7-8 months of age. Among Tx neonates, 82.4% had low B lymphocyte numbers at birth, and 29.4% had also low numbers of other lymphocyte subpopulations. Nevertheless, all children developed protective antibodies with similar antibody concentrations to the control group. Vaccine reactogenicity was similar in both groups and BCG healing was uneventful. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFAPESP, Brazil
dc.description.sponsorshipCAPES, Brazil
dc.format.extent404-407
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.relation.ispartofVaccine
dc.rightsAcesso restrito
dc.subjectImmunosuppressionen
dc.subjectGestationen
dc.subjectSolid organ transplantationen
dc.subjectVaccineen
dc.subjectImmunizationen
dc.titleResponse to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestationen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Div Pediat Infect Dis, Rua Pedro Toledo,781-9 Andar Sao Paulo, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Div Pediat Infect Dis, Rua Pedro Toledo,781-9 Andar Sao Paulo, BR-04039032 Sao Paulo, SP, Brazil
dc.description.sponsorshipIDFAPESP: 2008/11670-9
dc.identifier.doi10.1016/j.vaccine.2015.12.017
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000368868100003
dc.coverageOxford
dc.citation.volume34
dc.citation.issue4
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