Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/58542
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dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorSilva, Fernanda Pinheiro da [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorMiranda, Danielle Araujo de [UNIFESP]
dc.contributor.authorSantamarina, Aline Boveto [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorRosso, Veridiana Vera de [UNIFESP]
dc.date.accessioned2020-10-30T18:46:38Z
dc.date.available2020-10-30T18:46:38Z
dc.date.issued2016
dc.identifierhttps://doi.org/10.1186/s13098-015-0122-4
dc.identifier.citationDiabetology & Metabolic Syndrome. London, v. 8, p. -, 2016.
dc.identifier.issn1758-5996
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58542
dc.description.abstractBackground: The consumption of hyperlipidic and hypercaloric diet is considered a major factor to promote obesity and the consumption of food with antioxidant properties, like Jucara (Euterpe edulis Mart), could be a tool to prevent the deleterious effect of high white adipose deposition. The aim of the present study was to evaluate the effect of administration of jucara pulp in mice fed a high-fat, high-calorie diet on glucose tolerance and adipose tissue inflammatory status. Methods: Mice were distributed into the following groups: control diet; control diet plus 0.5 % of jucara; control diet plus 2 % of jucara; hypercaloric and hyperlipidic diet; hypercaloric and hyperlipidic diet plus 0.5 % of jucara and hypercaloric and hyperlipidic diet plus 2 % of jucara. Treatments started when mice were 8 weeks old and carried on for a total period of 10 weeks. The serum glucose, triacylglycerol, total cholesterol, insulin, adiponectin, lipopolysaccharides and free fatty acids concentrations were measured. Oral glucose tolerance test was performed. TNF-alpha, IL-6, and IL-10 protein level were determined by ELISA on mesenteric and epididymal white adipose tissues. Determination of catalase activity was realized in the same tissues. Data were analysed using one-way analysis of variance and post hoc analysis was performed with the Tukey's test. Results: The addition of 0.5 % jucara improved glycemic response in animals that consumed normocaloric as well as hypercaloric and hyperlipidic diets (HC). Supplementation with 0.5 and 2 % did not change the body composition of animals that received the HC diet; however, the animals fed the normocaloric diet with 2 % jucara gained body mass. An intake of 2 % jucara in the HC diet promoted a reduction of catalase activity and IL-10 level in epididymal adipose tissue. Conclusions: These results suggest that with the administration of 0.5 % jucara, the beneficial effects of polyphenols overcome the deleterious effects of macronutrient composition of jucara, whereas with the administration of 2 % jucara promotes damage by the composition of the fruit and overshadows the beneficial effects of polyphenols on glucose metabolism. On the other hand, higher jucara supplementation improves the inflammatory status targeted by the HC diet.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.format.extent-
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofDiabetology & Metabolic Syndrome
dc.rightsAcesso aberto
dc.subjectJucaraen
dc.subjectEuterpe edulis Marten
dc.subjectObesityen
dc.subjectInflammationen
dc.subjectMiceen
dc.subjectAnthocyaninsen
dc.titleJucara pulp supplementation improves glucose tolerance in miceen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Rua Botucatu,862 Vila Clementino, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Rua Botucatu,862 Vila Clementino, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Sao Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2009/53884-8
dc.description.sponsorshipIDFAPESP: 2013/12325-1
dc.identifier.fileWOS000368572700002.pdf
dc.identifier.doi10.1186/s13098-015-0122-4
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000368572700002
dc.coverageLondon
dc.citation.volume8
Appears in Collections:Artigo
Artigo

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