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dc.contributor.authorMarques-Carneiro, Jose Eduardo [UNIFESP]
dc.contributor.authorNehlig, Astrid
dc.contributor.authorCassel, Jean-Christophe
dc.contributor.authorFerreira Castro-Neto, Eduardo [UNIFESP]
dc.contributor.authorLitzahn, Julia Julie [UNIFESP]
dc.contributor.authorde Vasconcelos, Anne Pereira
dc.contributor.authorNaffah-Mazacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorda Silva Fernandes, Maria Jose [UNIFESP]
dc.identifier.citationPharmaceuticals. Basel, v. 10, n. 4, p. -, 2017.
dc.description.abstractThe administration of lithium-pilocarpine (LiPilo) in adult rats is a validated model reproducing the main clinical and neuropathological features of temporal lobe epilepsy (TLE). Previous studies have shown that carisbamate (CRS) has the property of modifying epileptogenesis in this model. When treated with CRS, about 50% of rats undergoing LiPilo status epilepticus (SE) develop non-convulsive seizures (NCS) instead of convulsive ones (commonly observed in TLE). The goal of this work was to determine some of the early changes that occur after CRS administration, as they could be involved in the insult- and epileptogenesis-modifying effects of CRS. Thus, we performed high-performance liquid chromatography (HPLC) to quantify levels of amino acids and monoamines, and c-Fos immunohistochemical labeling to map cerebral activation during seizures. Comparing rats treated one hour after SE onset with saline (CT), CRS, or diazepam (DZP), HPLC showed that 4 h after SE onset, dopamine (DA), norepinephrine (NE), and GABA levels were normal, whereas serotonin levels were increased. Using c-Fos labeling, we demonstrated increased activity in thalamic mediodorsal (MD) and laterodorsal (LD) nuclei in rats treated with CRS. In summary, at early times, CRS seems to modulate excitability by acting on some monoamine levels and increasing activity of MD and LD thalamic nuclei, suggesting a possible involvement of these nuclei in insult- and/or epileptogenesis-modifying effects of CRS.en
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal deNivel Superior-CAPES-Brasil
dc.description.sponsorshipFundacao de Amparo a Pesquisa no Estado de Sao Paulo-FAPESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
dc.description.sponsorshipFundacao de Apoio a Unifesp-FAP-UNIFESP, Brazil
dc.publisherMdpi Ag
dc.rightsAcesso aberto
dc.subjectcarisbamate 1en
dc.subjecttemporal-lobe epilepsy 2en
dc.subjectbrain activity 3en
dc.titleNeurochemical Changes and c-Fos Mapping in the Brain after Carisbamate Treatment of Rats Subjected to Lithium-Pilocarpine-Induced Status Epilepticusen
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol Neurocirurgia, Disciplina Neurociencia, BR-04021001 Sao Paulo, Brazil
dc.description.affiliationUniv Strasbourg, Fac Psychol, Lab Neurosci Cognit & Adaptat, Unistra, F-67000 Strasbourg, France
dc.description.affiliationCNRS, LNCA, UMR 7364, 12 Rue Goethe, F-67000 Strasbourg, France
dc.description.affiliationINSERM, U1129, Infantile Epilepsies & Brain Plast, F-75654 Paris, France
dc.description.affiliationUniv Paris 05, Sorbonne Paris Cite, F-91190 Gif Sur Yvette, France
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol Neurocirurgia, Disciplina Neurociencia, BR-04021001 Sao Paulo, Brazil
dc.description.sourceWeb of Science
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