Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/57323
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dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorSilva, Fernanda Pinheiro da [UNIFESP]
dc.contributor.authorMiranda, Danielle Araujo de [UNIFESP]
dc.contributor.authorSantamarina, Aline Boveto [UNIFESP]
dc.contributor.authorMennitti, Lais Vales [UNIFESP]
dc.contributor.authorMoreira, Renata Guimaraes
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.date.accessioned2020-08-04T13:40:09Z
dc.date.available2020-08-04T13:40:09Z
dc.date.issued2017
dc.identifierhttps://dx.doi.org/10.1002/ejlt.201600384
dc.identifier.citationEuropean Journal Of Lipid Science And Technology. Hoboken, v. 119, n. 10, p. -, 2017.
dc.identifier.issn1438-7697
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57323
dc.description.abstractThis study evaluated effects of integral chia flour (Salvia hispanica L.) associated with high‐fat diet on glucose metabolism, fatty acid profile, and inflammatory mediators in epididymal adipose and liver tissue using experimental obesity models induced by high‐calorie and ‐fat diets. Forty‐eight mice were divided into four experimental groups: control diet (C); control diet + chia flour (CCh); high‐fat and ‐calorie diet (H), and high‐fat and ‐calorie diet + chia flour (HCh). Tissue cytokines, fatty acid profile, and glycaemic profile were measured. In oral glucose tolerance testing, HCh presented higher glycaemia than H at 15, 30, and 120 min. In epididymal adipose tissue, CCh showed higher accumulation of alpha‐linolenic fatty acid (α‐LNA) than C, while HCh showed higher accumulation of α‐LNA and lower concentrations of C20:4n6 fatty acid than H. In liver tissue, CCh presented higher accumulation of α‐LNA and lower concentrations of C20:4n6 fatty acid than C. We believe that 12 g of chia flour per kg of food for 10 wk is essential for prevention and treatment of obesity; however, it may be necessary to adjust chia amounts and treatment times to improve glycaemic profiles. This study provides pioneering results on the effects of chia in mice. Practical applications: With the hope of losing weight and becoming healthier, many people adopt radical diets that can be harmful to their health. Accordingly, dietary guidelines must be carefully planned by qualified health professionals, especially considering the comorbidities of diabetes and cardiovascular disease that accompany obesity. In addition, the adequate treatment of obesity increases the chances of the patients maintaining their diet and lifestyle changes, thus, allowing for greater control of their obesity. Consequently, knowledge of the appropriate dosages and effects of chia is important for the development of new tools for composing dietary guidelines for healthy individuals, especially for the treatment of obese patients.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.format.extent-
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofEuropean Journal Of Lipid Science And Technology
dc.rightsAcesso restrito
dc.subjectChiaen
dc.subjectFatty aciden
dc.subjectGlucose metabolismen
dc.subjectInflammationen
dc.subjectObesityen
dc.titleChia (Salvia hispanica L.) flour promotes beneficial effects on adipose tissue but not on glycaemic profile of diet-induced obesity in miceen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Interdisciplinaridade Ciencias Saude, Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, Inst Saude & Soc, Santos, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Fisiol, Inst Biociencias, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Interdisciplinaridade Ciencias Saude, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, Inst Saude & Soc, Santos, SP, Brazil
dc.description.sponsorshipIDFAPESP: 2013/12410-9
dc.identifier.doi10.1002/ejlt.201600384
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000412122500004
dc.coverageHoboken
dc.citation.volume119
dc.citation.issue10
Appears in Collections:EPM - Artigos
ISS - Artigos

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