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dc.contributor.authorLarangeira, Paula Martins [UNIFESP]
dc.contributor.authorRosso, Veridiana Vera de [UNIFESP]
dc.contributor.authorSilva, Victor Hugo Pereira da [UNIFESP]
dc.contributor.authorMoura, Carolina Foot Gomes de [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.identifier.citationExperimental And Toxicologic Pathology. Jena, v. 68, n. 10, p. 571-578, 2016.
dc.description.abstractThe ionic liquid or melted salt 1-Butyl-3-methylimidazolium is an alternative process to extract natural pigments, such as carotenoids. Lycopene represents 80-90% of total of carotenoids presents in tomatoes and it has been widely studied due its potent antioxidant action. The aim of this study was to evaluate genotoxicity, mutagenicity and cytotoxicity of carotenoids extracted from ionic liquid using experimental model in vivo. For this purpose, a total of 20 male Wistar rats were distributed into four groups (n = 5), as follows: control groupen
dc.description.abstractreceived a corresponding amount of corn oil for 7 days by intragastric gavage (i.g.), ionic liquid group, received 10 mg kg(-1) body weight for 7 days by gavageen
dc.description.abstract10 mg carotenoids group, received 10 mg kg(-1) bw dissolved in corn oil for 7 days by gavage and 500 mg carotenoids group, received 500 mg kg(-1) bw dissolved in corn oil for 7 days by gavage. Rat liver treated with ionic liquid exhibited moderate histopathological changes randomly distributed in the parenchyma, such as cytoplasmic eosinophilia, apoptotic bodies, inflammatory infiltrate and focal necrosis. DNA damage was found in peripheral blood and liver cells of rats treated with ionic liquid or carotenoids at 500 mg. An increase of micronucleated cells and 8-OhDG immunopositive cells were also detected in rats treated with carotenoids at 500 mg. In summary, our results demonstrate that recommended dose for human daily intake of carotenoids extracted by ionic liquid did not induce genotoxicity, mutagenicity and cytotoxicity in multiple organs of rats. (C) 2016 Elsevier GmbH. All rights reserved.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartofExperimental And Toxicologic Pathology
dc.rightsAcesso restrito
dc.subjectIonic liquiden
dc.titleGenotoxicity, mutagenicity and cytotoxicity of carotenoids extracted from ionic liquid in multiples organs of Wistar ratsen
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, UNIFESP, Av Ana Costa 95, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespDepartment of Biosciences, Universidade Federal de São Paulo (UNIFESP), SP, Brazil
dc.description.sourceWeb of Science
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