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dc.contributor.authorLevandowski, Mateus Luz
dc.contributor.authorTractenberg, Saulo Gantes
dc.contributor.authorde Azeredo, Lucas Araujo
dc.contributor.authorDe Nardi, Tatiana
dc.contributor.authorRovaris, Diego L.
dc.contributor.authorBau, Claiton H. D.
dc.contributor.authorRizzo, Lucas Bortolotto [UNIFESP]
dc.contributor.authorMaurya, Pawan Kumar [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorTyrka, Audrey R.
dc.contributor.authorGrassi-Oliveira, Rodrigo
dc.identifier.citationProgress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 71, p. 83-89, 2016.
dc.description.abstractBackground: Early life stress (ELS) and addiction are related to age-related diseases and telomere shortening. However, the role of telomere length (TL) in crack cocaine addiction remains unknown. The purpose of this study was to investigate the TL in a sample of crack cocaine dependent-women who reported an ELS history and in a community-based sample of elderly women as a reference group for senescence. Methods: This study included treatment seeking crack cocaine dependents women (n = 127) and elderly women without a psychiatric diagnosis (ELD, n = 49). The crack cocaine sample was divided in two groups according to their Childhood Trauma Questionnaire (CTQ) scores: presence of history of childhood abuse and neglect (CRACK-ELS) and absence of ELS history (CRACK). TL was assessed by T/S ratio obtained from peripheral blood DNA using quantitative PCR assay. esults: CRACK and CRACK-ELS subjects exhibited shortened TL in comparison to the ELD group, despite their younger age. Among crack cocaine sample, CRACK-ELS group had significantly shorter telomeres than the CRACK group. Correlation analysis within crack cocaine group indicated that TL was negatively correlated with emotional abuse scores. Conclusions: These results support previous findings associating telomere shortening with both ELS and drug addiction. This study suggests new evidence of a distinct biological phenotype for drug-dependent women with ELS. The results support the biological senescence hypothesis underpinning ELS experience. (C) 2016 Elsevier Inc. All rights reserved.en
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofProgress In Neuro-Psychopharmacology & Biological Psychiatry
dc.rightsAcesso restrito
dc.subjectChild abuseen
dc.subjectSubstance-related disordersen
dc.titleCrack cocaine addiction, early life stress and accelerated cellular aging among womenen
dc.description.affiliationPontifical Catholic Univ Rio Grande Sul PUCRS, Biomed Res Inst IPB, DCNL, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Inst Biociencias, Dept Genet, Porto Alegre, RS, Brazil
dc.description.affiliationFed Univ Sao Paulo Unifesp, Dept Psychiat, Res Grp Behav Neurosci Bipolar Disorder, Sao Paulo, SP, Brazil
dc.description.affiliationBrown Univ, Mood Disorders Res Program, Providence, RI 02912 USA
dc.description.affiliationBrown Univ, Dept Psychiat & Human Behav, Lab Clin & Translat Neurosci, Providence, RI 02912 USA
dc.description.affiliationUnifespResearch Group in Behavioral Neuroscience of Bipolar Disorder, Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
dc.description.sourceWeb of Science
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