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Title: Acute crack cocaine exposure induces genetic damage in multiple organs of rats
Authors: Moretti, Eduardo Gregolin [UNIFESP]
Yujra, Veronica Quispe [UNIFESP]
Claudio, Samuel Rangel [UNIFESP]
Silva, Marcelo Jose Dias
Vilegas, Wagner
Pereira, Camilo Dias Seabra [UNIFESP]
De Oliveira, Flavia [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Crack cocaine
Genomic instability
DNA damage
Issue Date: 2016
Publisher: Springer Heidelberg
Citation: Environmental Science And Pollution Research. Heidelberg, v. 23, n. 8, p. 8104-8112, 2016.
Abstract: Crack cocaine is a very toxic product derived from cocaine. The aim of this study was to evaluate genetic damage in multiple organs of rats following acute exposure to crack cocaine. A total of 20 Wistar rats were distributed into four groups (n = 5), as follows: 0, 4.5, 9, and 18 mg/kg body weight (b.w.) of crack cocaine administered by intraperitoneal route (i.p.). All animals were killed 24 h after intraperitoneal (i.p.) injection. The results showed that crack cocaine increased the number of micronucleated cells in bone marrow cells exposed to 18 mg/kg crack cocaine (p < 0.05). Peripheral blood and liver cells presented genetic damage as depicted by single cell gel (comet) assay at 9 and 18 mg/kg doses (p < 0.05). Immunohistochemistry data revealed significant increase in 8-hydroxy-20-deoxyguanosine (8-OHdG) immunoexpression in hepatocytes of animals exposed to crack cocaine at 9 and 18 mg/kg (p < 0.05) when compared with negative controls. Taken together, our results demonstrate that crack cocaine is able to induce genomic damage in multiple organs of Wistar rats.
ISSN: 0944-1344
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