Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/55744
Title: The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression
Authors: Silva, Marcelo Jose Dias
Vilegas, Wagner
Silva, Marcelo Aparecido da
Paiotti, Ana Paula Ribeiro [UNIFESP]
Pastrelo, Mauricio Mercaldi [UNIFESP]
Ruiz, Pedro Luiz Menin [UNIFESP]
Moura, Carolina Foot Gomes de [UNIFESP]
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Keywords: inflammatory bowel disease
TNBS-colitis
mimosa
TNF-alpha
COX-2
Issue Date: 2018
Publisher: Georg Thieme Verlag Kg
Citation: Drug Research. Stuttgart, v. 68, n. 4, p. 196-204, 2018.
Abstract: The aim of this study was to evaluate the preventive and/or protective action of Mimosa caesalpiniifolia (M. caesalpiniifolia) following experimental colitis in rats. The rats were randomized into ten groups (n = 10 per group), as follows: G1 - Sham group:
G2 - TNBS group
G3, G4 - colitis and treated with hydroalcoholic extract of M. caesalpiniifolia 250 mg/kg/day after and before/after inducing colitis, respectively
G5, G6 - colitis and treated with hydroalcoholic extract of M. caesalpiniifolia at 125 mg/kg/day after and before/after inducing colitis respectively
G7, G8 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/ after inducing colitis, respectively
G9, G10 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively. Rats treated with hydroalcoholic extract of M. caesalpiniifolia for both doses showed lower tissue damage in the distal colon. Ethylacetate fraction was effective at the highest dose only when administrated after inducing colitis. A downregulation of COX-2 was detected to rats suffering colitis and treated with M. caesalpiniifolia at high dose. On the other hand, TNF-alpha immunoexpression decreased in groups treated with M. caesalpiniifolia at low dose after inducing colitis. In summary, our results suggest that M. caesalpiniifolia attenuated the lesions of the colon, reduced inflammation, and modulates the expression of COX-2 and TNF-alpha during chronic colitis induced by TNBS when using for therapeutic purposes on a dose-dependent manner.
URI: https://repositorio.unifesp.br/handle/11600/55744
ISSN: 2194-9379
Other Identifiers: http://dx.doi.org/10.1055/s-0043-119750
Appears in Collections:EPM - Artigos
ISS - Artigos

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