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dc.contributor.authorSethi, Sumit [UNIFESP]
dc.contributor.authorHayashi, Mirian A. [UNIFESP]
dc.contributor.authorSussulini, Alessandra
dc.contributor.authorTasic, Ljubica
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.identifier.citationWorld Journal Of Biological Psychiatry. Abingdon, v. 18, n. 7, p. 506-520, 2017.
dc.description.abstractObjectives: In this review, the authors discuss an overview of lipidomics followed by in-depth discussion of its application to the study of human diseases, including extraction methods of lipids, analytical techniques and clinical research in neuropsychiatric disorders. Methods: Lipidomics is a lipid-targeted metabolomics approach aiming at the comprehensive analysis of lipids in biological systems. Recent technological advancements in mass spectrometry and chromatography have greatly enhanced the development and applications of metabolic profiling of diverse lipids in complex biological samples. Results: An effective evaluation of the clinical course of diseases requires the application of very precise diagnostic and assessment approaches as early as possible. In order to achieve this, omics strategies offer new opportunities for biomarker identification and/or discovery in complex diseases and may provide pathological pathways understanding for diseases beyond traditional methodologies. Conclusions: This review highlights the importance of lipidomics for the future perspectives as a tool for biomarker identification and discovery and its clinical application.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brasilia, Brazil)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo, Brazil)
dc.description.sponsorshipFundo de Apoio ao Ensino, a Pesquisa e a Extensao (FAEPEX) from the Universidade Estadual de Campinas
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofWorld Journal Of Biological Psychiatry
dc.rightsAcesso restrito
dc.subjectbipolar disorderen
dc.subjectmajor depressive disorderen
dc.titleAnalytical approaches for lipidomics and its potential applications in neuropsychiatric disordersen
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, Res Bldg II,Rua Pedro Toledo, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas UNICAMP, Inst Chem, Dept Organ Chem, Campinas, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, Res Bldg II,Rua Pedro Toledo, Sao Paulo, Brazil
dc.description.sponsorshipIDCNPq: 454234/2014-7
dc.description.sponsorshipIDFAPESP: 2014/18938-8
dc.description.sponsorshipIDFAEPEX/UNICAMP: 1244/14
dc.description.sourceWeb of Science
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