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Title: Propionibacterium acnes Enhances the Immunogenicity of HIVBr18 Human Immunodeficiency Virus-1 Vaccine
Authors: Teixeira, Daniela [UNIFESP]
Ishimura, Mayari Eika [UNIFESP]
Apostolico, Juliana de Souza [UNIFESP]
Viel, Jacqueline Miyuki [UNIFESP]
Passarelli, Victor Cabelho [UNIFESP]
Cunha-Neto, Edecio
Rosa, Daniela Santoro [UNIFESP]
Longo-Maugeri, Ieda Maria [UNIFESP]
Keywords: Propionibacterium acnes
human immunodeficiency virus-1
DNA vaccine
CD4(+) T cell
Issue Date: 2018
Publisher: Frontiers Media Sa
Citation: Frontiers In Immunology. Lausanne, v. 9, p. -, 2018.
Abstract: Immunization of BALB/c mice with HIVBr18, a DNA vaccine containing 18 CD4(+) T cell epitopes from human immunodeficiency virus (HIV), induced specific CD4(+) and CD8(+) T cell responses in a broad, polyfunctional and persistent manner. With the aim of increasing the immunogenicity of this vaccine, the effect of Propionibacterium acnes as an adjuvant was evaluated. The adjuvant effects of this bacterium have been extensively demonstrated in both experimental and clinical settings. Herein, administration of two doses of HIVBr18, in the presence of P. acnes, increased the proliferation of HIV-1-specific CD4(+) and CD8(+) T lymphocytes, the polyfunctional profile of CD4(+) T cells, the production of IFN-gamma, and the number of recognized vaccine-encoded peptides. One of the bacterial components responsible for most of the adjuvant effects observed was a soluble polysaccharide extracted from the P. acnes cell wall. Furthermore, within 10 weeks after immunization, the proliferation of specific T cells and production of IFN-gamma were maintained when the whole bacterium was administered, demonstrating a greater effect on the longevity of the immune response by P. acnes. Even with fewer immunization doses, P. acnes was found to be a potent adjuvant capable of potentiating the effects of the HIVBr18 vaccine. Therefore, P. acnes may be a potential adjuvant to aid this vaccine in inducing immunity or for therapeutic use.
ISSN: 1664-3224
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