Please use this identifier to cite or link to this item:
Title: Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative
Authors: Guimaraes, Julio Brandao [UNIFESP]
Nevitt, Michael C.
McCulloch, Charles E.
Schwaiger, Benedikt J.
Gersing, Alexandra S.
Facchetti, Luca
Bucknor, Matthew D.
Chanchek, Nattagan
Liu, Felix
Joseph, Gabby B.
Link, Thomas M.
Keywords: Magnetic resonance imaging
Meniscal intrasubstance degeneration
Meniscal tears
Weight change
Meniscal lesion
Issue Date: 2018
Publisher: Springer
Citation: European Radiology. New York, v. 28, n. 3, p. 953-962, 2018.
Abstract: To investigate the association of weight change over 48 months with progression of meniscal intrasubstance degeneration (MID). We studied 487 subjects with MID at baseline and after 48 months using 3-T MRI with the same protocol (FSE sequences with and without fat suppression). These participants lost weight (ae<yen>3%, n = 141), had moderate weight gain (3-10%, n = 77), substantial weight gain (> 10%, n = 15) or maintained stable weight (n = 254). Progression of MID to a meniscal tear was assessed using the WORMS grading system and compared among weight change groups using logistic regression. ANOVA and chi-square tests were used to study the differences in subjects' characteristics. Progression of MID increased from weight loss to substantial weight gain (p < 0.001) and was significantly more likely with both moderate weight gain (odds ratio [OR], 4.9
95% confidence interval [CI] 2.4-8.9) and substantial weight gain (OR, 9.5
95% CI 3.2-28.5) compared to stable weight. Results were similar in both menisci for moderate weight gain (medial: OR, 6.8
95% CI 3.5-11.3
lateral: OR, 2.6
95% CI 1.1-6.6) and substantial weight gain (medial: OR, 21.0
95% CI 5.1-80.7
lateral: OR, 9.7
95% CI 0.95-100.2). Weight gain is associated with an increased likelihood that meniscal intrasubstance degeneration will progress with the risk increasing with greater weight gain.
ISSN: 0938-7994
Other Identifiers:
Appears in Collections:Artigo

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.