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Authors: Canuto, Gisele A. B.
da Costa, Jose Luiz
da Cruz, Pedro L. R.
de Souza, Ana Rosa L.
Faccio, Andrea T.
Klassen, Aline [UNIFESP]
Rodrigues, Karina T.
Tavares, Marina F. M.
Keywords: metabolomics
untargeted metabolomics
targeted metabolomics
metabolomics workflow
Issue Date: 2018
Publisher: Soc Brasileira Quimica
Citation: Quimica Nova. Sao Paulo, v. 41, n. 1, p. 75-91, 2018.
Abstract: Metabolomics is an emerging and promising omics approach used to understand biological mechanisms. By untargeted and targeted metabolomics analyses, metabolites are determined in biological samples (fluids, cells, tissues, etc.) by comparison of control groups with altered groups, undergoing different therapies, submitted to differing stress levels, dietary modulation, or promoted by a disease, or specific condition, etc., using sophisticated analytical techniques, and advanced data treatment and statistical analyses. In this review, the concepts involved in metabolomics studies were presented, describing in details all steps involved in the metabolomics workflow, for untargeted and targeted strategies. Finally, the potential of metabolomics is illustrated by applications in representative areas: clinical, environmental, food and nutrition, forensic toxicology, microbiology, parasitology, plants, and sports. Relevant reviews were compiled to characterize each of these areas, and a corresponding application of untargeted and targeted metabolomics were described.
ISSN: 0100-4042
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