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Title: Effects of hyperprolactinemia on the tibial epiphyseal plate of mice treated with sex hormones
Authors: Wolff, Roberta Bastos [UNIFESP]
Gomes, Regina Célia Teixeira [UNIFESP]
do Amaral, Vinicius C.
da Silva, Priscilla L.
Simoncini, Tommaso
Prosdocimi, Fabio Cesar
Simoes, Ricardo Santos
Simões, Manuel de Jesus S. [UNIFESP]
Baracat, Edmund Chada
Soares Júnior, José Maria [UNIFESP]
Keywords: Estrogens
Hormone Replacement Therapy
OsteoporosisProlactin Receptor Expression
Uterine Prolactin
Trabecular Bone
Knockout Mice
Issue Date: 2016
Publisher: Cuba Editora
Citation: Gynecological Endocrinology. Abingdon, v. 32, n. 1, p. 30-33, 2016.
Abstract: The aim of this study was to evaluate the effects of metoclopramide-induced hyperprolactinemia on the tibial epiphyseal plate of hormone-treated oophorectomized mice. For this purpose, 18 animals with intact ovaries were allocated to two groups, M (metoclopramide) and V (vehicle). One hundred and eight oophorectomized animals were allocated to 12 subgroups: Oophx/V (vehicle)
Ooph/M (metoclopramide)
Oophx/V+E (vehicle+estradiol)
Oophx/M+E (metoclopramide+estradiol)
Oophx/V+P (vehicle+progesterone)
Oophx/M+P (metoclopramide+progesterone)
Oophx/V+T (vehicle+testosterone)
Oophx/M+T (metoclopramide+testosterone)
Oophx/V+E+P (Vehicle+estradiol+progesterone)
Oophx/M+E+P (metoclopramide+estradiol+progesterone)
Oophx/V+E+P+T (vehicle+estradiol+progesterone+testosterone)
Oophx/M+E+P+T (metoclopramide+estradiol+progesterone+testosterone). After a 50-day treatment was performed histomorphometric and immunohistochemical cell death analysis. In the epiphyseal plate of the hyperprolactinemic and/or oophorectomized animals, cell proliferation and bone formation decreased, inducing intensified cell death. In the sex steroid-treated animals, estrogen boosted cell proliferation
progesterone, bone formation and testosterone, both cell proliferation and bone formation. These findings suggest that oophorectomy and hyperprolactinemia changed epiphyseal plate morphology causing cartilage degeneration. Treatment with combined sex steroids may diminish such deleterious effects.
ISSN: 0951-3590
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