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Title: Resident Peritoneal Inflammatory Cells are Pivotal in the Development of Experimental Atherosclerosis
Authors: Relvas, Waldir Gabriel Miranda [UNIFESP]
Izar, Maria Cristina de Oliveira [UNIFESP]
Segreto, Helena Regina Comodo [UNIFESP]
Giordani, Adelmo José [UNIFESP]
Ihara, Silvia Saiuli Miki [UNIFESP]
Mariano, Mario [UNIFESP]
Lopes, Jose Daniel [UNIFESP]
Popi, Ana Flavia [UNIFESP]
Helfenstein, Tatiana [UNIFESP]
Pomaro, Daniel Roberto [UNIFESP]
Póvoa, Rui Manuel dos Santos [UNIFESP]
Carvalho, Antonio Carlos [UNIFESP]
Fonseca, Francisco Antonio Helfenstein [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Atherogenesis
Peritoneal cells
Ionizing radiation
Issue Date: 1-Jan-2010
Publisher: Japan Atherosclerosis Soc
Citation: Journal Of Atherosclerosis And Thrombosis. Tokyo: Japan Atherosclerosis Soc, v. 17, n. 4, p. 378-385, 2010.
Abstract: Aim: Based on evidence that ionizing radiation can ameliorate chronic and autoimmune diseases in patients and experimental animals, we investigated the effects of radiation on the induction and development of experimental atherogenesis.Methods: Male New Zealand rabbits were divided into 5 groups and given an atherogenic diet for 90 days. Peritoneal and thoracic areas (9 Gy) were irradiated on the 1st and 45th days for groups 1 and 2, the 45th day for groups 3 and 4, and not at all for group 5. Prior to irradiation, the peritoneal cavity of animals from groups 1 and 3 was washed with buffered saline. Cells collected by peritoneal washing were reinfused into the peritoneal cavity of the same animal after irradiation. Animals from groups 2 and 4 were intraperitoneally injected with saline as a control.Results: Despite similar lipid profiles among the experimental groups, the percentage of aortas covered by plaques was remarkably reduced (p < 0.001) among animals submitted to irradiation (groups 2 and 4). These differences were completely abolished in irradiated animals reconstituted with their own peritoneal cells.Conclusions: These findings point to an important role of resident inflammatory peritoneal cells in experimental atherogenesis.
ISSN: 1340-3478
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