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Title: Apolipoprotein A-V gene polymorphism -1131T > C and Alzheimer's disease
Authors: Barbosa, Fabio Augusto Freiria
Labio, Roger Willian de
Rigolin, Valdeci Oliveira Santos [UNIFESP]
Minett, Thaís Soares Cianciarullo [UNIFESP]
Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Smith, Marilia de Arruda Cardoso [UNIFESP]
Payão, Spencer Luiz Marques [UNIFESP]
Fac Med Marilia
Universidade Federal de São Paulo (UNIFESP)
Univ Marilia
Univ Sagrado Coracao
Keywords: ageing
Alzheimer's disease
apolipoprotein A5
1131T -> polymorphisms
risk factor
Issue Date: 1-Dec-2006
Publisher: Ios Press
Citation: Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 10, n. 4, p. 365-369, 2006.
Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly and is also considered a progeroid genetic syndrome. The etiology of AD is complex and the mechanisms underlying its pathophysiology remain to be claritied. It has been suggested that a high serum cholesterol level is a risk factor for (AD), and that some polymorphisms of genes encoding proteins regulating cholesterol metabolism are associated with AD development. APOA5 is a recently discovered apolipoprotein involved primarily with triglyceride JG) metabolism disorder. This study investigates the association of AD with the APOA5 gene - 1131T > C polymorphisms in samples of 106 patients with Alzheimer's disease (AD), 76 elderly healthy controls and 93 young healthy controls. DNA samples were isolated from blood cells, amplified by PCR and digested with Tru11. We observed that the genotype distributions of APOA5 variants were within Hardy-Weinberg equilibrium in all subject samples. Furthermore, chi-square test comparison for genotype distributions and allele frequencies did not reveal any significant difference among the three groups of subjects (P > 0.05). These results support the idea that these variants are not involved as a risk factor for developing AD.
ISSN: 1387-2877
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