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Title: Effect of Cross-Linking on Corneal Thickness in Patients With Corneal Edema
Authors: Barbosa, Manuela Maria Valença Cordeiro [UNIFESP]
Barbosa, Jose Bonifacio [UNIFESP]
Hirai, Flávio Eduardo [UNIFESP]
Hofling-Lima, Ana Luisa [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: cross-linking
corneal edema
bullous keratopathy
Issue Date: 1-Jun-2010
Publisher: Lippincott Williams & Wilkins
Citation: Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 29, n. 6, p. 613-617, 2010.
Abstract: Purpose: To investigate the pachymetric changes of collagen cross-linking in corneas with edema because of endothelial dysfunction.Methods: Interventional case series included 25 eyes of 25 consecutive patients with corneal edema for at least 4 months related to Fuchs endothelial dystrophy, corneal graft failure, and postoperative bullous keratopathy. Central corneal thickness was measured preoperatively, 1, 3, and 6 months after the procedure by ultrasound pachymetry and optical coherence tomography.Results: Mean central corneal thickness measured by ultrasound pachymetry decreased after corneal cross-linking (mean +/- SD): 712.0 +/- 99.7, 618.3 +/- 103.0, and 657.5 +/- 114.8 for preoperative, 1-, and 3-month follow-up, respectively. Differences between preoperative value and 1- and 3-month follow-up values were statistically significant (P < 0.01). Similar results were found with the optical coherence tomography (mean +/- SD): 777.3 +/- 131.0, 711.6 +/- 133.1, 746.4 +/- 142.4, and 830.6 +/- 198.7, for preoperative, 1-, 3-, and 6-month follow-up values, respectively. Fourteen patients (56%) developed new epithelial bullae after 3 months; 11 patients (44%) remained asymptomatic until their last visit.Conclusion: Corneal cross-linking showed to be a sate procedure and potential therapeutic alternative for the treatment corneal edema.
ISSN: 0277-3740
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