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Title: Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function
Authors: Brum, P. C.
Bacurau, A. V. N.
Medeiros, A. [UNIFESP]
Ferreira, J. C. B.
Vanzelli, A. S.
Negrao, C. E.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Stanford Univ
Keywords: Heart failure
Exercise training
Sympathetic hyperactivity
Ventricular function
Cardiac remodeling
Skeletal myopathy
Issue Date: 1-Sep-2011
Publisher: Assoc Bras Divulg Cientifica
Citation: Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 44, n. 9, p. 827-835, 2011.
Abstract: Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.
ISSN: 0100-879X
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