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dc.contributor.authorPaiva, Marcos Bandiera [UNIFESP]
dc.contributor.authorJoo, Jayne
dc.contributor.authorAbrahão, Márcio [UNIFESP]
dc.contributor.authorRibeiro, Joao Carlos [UNIFESP]
dc.contributor.authorCervantes, Onivaldo [UNIFESP]
dc.contributor.authorSercarz, Joel A.
dc.identifier.citationAnti-cancer Agents In Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 11, n. 8, p. 772-779, 2011.
dc.description.abstractAlthough major progress has been made in surgery, radiation, and chemotherapy for the treatment of malignancy during the last 20 years, there has been little improvement in the survival of patients with recurrent or advanced head and neck cancer. Because of the ease and accessibility for surgery and their loco-regional biological behavior, head and neck cancers serve as an ideal model to test combined laser energy delivered via interstitial fiberoptics and chemotherapeutic agents activated by photo-thermal energy as an alternative, less invasive treatment for cancer. A number of investigators have shown that anthracyclines and cisplatin are likely candidates for light or heat activation in cancer cells. Maximum tolerated dose followed by photochemical and thermal activation via laser fiberoptics can improve treatment by sensitizing tumor response. The higher intratumor drug levels compared to systemic drug administration along with laser activation should also reduce systemic toxicity. In this article the authors analyze the concept of combining anti-cancer drugs and laser therapy and review the clinical application. In summary, the literature available suggests photochemotherapy with currently approved drugs and lasers may soon become an attractive alternative for cancer treatment.en
dc.description.sponsorshipDivision of Head and Neck Surgery
dc.description.sponsorshipJonsson Comprehensive Cancer
dc.description.sponsorshipDavid Geffen School of Medicine at UCLA, National Cancer Institute - NIH
dc.description.sponsorshipFundacao de Amparo a Pesquisa no Estado de Sao Paulo
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofAnti-cancer Agents In Medicinal Chemistry
dc.rightsAcesso restrito
dc.subjectcombined intratumor therapyen
dc.subjectlaser-induced thermal therapyen
dc.titleUpdate on Laser Photochemotherapy: An Alternative for Cancer Treatmenten
dc.contributor.institutionUniv Calif Los Angeles
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Calif Davis
dc.description.affiliationUniv Calif Los Angeles, David Geffen Sch Med, Dept Surg, Div Head & Neck Surg, Los Angeles, CA 90095 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Otolaryngol & Head & Neck Surg, Div Head & Neck Surg, Sao Paulo, Brazil
dc.description.affiliationUniv Calif Davis, Dept Otolaryngol, Davis, CA 95616 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Otolaryngol & Head & Neck Surg, Div Head & Neck Surg, Sao Paulo, Brazil
dc.description.sponsorshipIDDavid Geffen School of Medicine at UCLA, National Cancer Institute - NIH: K22 CA13985-02
dc.description.sponsorshipIDFundacao de Amparo a Pesquisa no Estado de Sao Paulo: 08/54714-6
dc.description.sourceWeb of Science
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