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dc.contributor.authorBeluzi, Mercia
dc.contributor.authorPeres, Sidney B.
dc.contributor.authorHenriques, Felipe S.
dc.contributor.authorSertie, Rogerio A. L.
dc.contributor.authorFranco, Felipe O.
dc.contributor.authorSantos, Kaltinaitis B.
dc.contributor.authorKnobl, Pamela
dc.contributor.authorAndreotti, Sandra
dc.contributor.authorShida, Claudio S. [UNIFESP]
dc.contributor.authorNeves, Rodrigo X.
dc.contributor.authorFarmer, Stephen R.
dc.contributor.authorSeelaender, Marilia
dc.contributor.authorLima, Fabio B.
dc.contributor.authorBatista, Miguel L.
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 10, n. 3, 16 p., 2015.
dc.description.abstractCachexia is a multifactorial syndrome characterized by profound involuntary weight loss, fat depletion, skeletal muscle wasting, and asthenia; all symptoms are not entirely attributable to inadequate nutritional intake. Adipose tissue and skeletal muscle loss during cancer cachexia development has been described systematically. the former was proposed to precede and be more rapid than the latter, which presents a means for the early detection of cachexia in cancer patients. Recently, pioglitazone (PGZ) was proposed to exhibit anticancer properties, including a reduction in insulin resistance and adipose tissue loss; nevertheless, few studies have evaluated its effect on survival. for greater insight into a potential anti-cachectic effect due to PGZ, 8-week-old male Wistar rats were subcutaneously inoculated with 1 mL (2x10(7)) of Walker 256 tumor cells. the animals were randomly assigned to two experimental groups: TC (tumor + saline-control) and TP5 (tumor + PGZ/5 mg). Body weight, food ingestion and tumor growth were measured at baseline and after removal of tumor on days 7, 14 and 26. Samples from different visceral adipose tissue (AT) depots were collected on days 7 and 14 and stored at -80oC (5 to 7 animals per day/group). the PGZ treatment showed an increase in the survival average of 27.3%(P<0.01) when compared to TC. It was also associated with enhanced body mass preservation (40.7 and 56.3%, p<0.01) on day 14 and 26 compared with the TC group. the treatment also reduced the final tumor mass (53.4%, p<0.05) and anorexia compared with the TC group during late-stage cachexia. the retroperitoneal AT (RPAT) mass was preserved on day 7 compared with the TC group during the same experimental period. Such effect also demonstrates inverse relationship with tumor growth, on day 14. Gene expression of PPAR-gamma, adiponectin, LPL and C/EBP-alpha from cachectic rats was upregulated after PGZ. Glucose uptake from adipocyte cells (RPAT) was entirely re-established due to PGZ treatment. Taken together, the results demonstrate beneficial effects of PGZ treatment at both the early and final stages of cachexia.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titlePioglitazone Treatment Increases Survival and Prevents Body Weight Loss in Tumor-Bearing Animals: Possible Anti-Cachectic Effecten
dc.contributor.institutionUniv Mogi das Cruzes
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBoston Sch Med
dc.description.affiliationUniv Mogi das Cruzes, Integrated Grp Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Canc Metab Res Grp, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Physiol Lab, São Paulo, Brazil
dc.description.affiliationUniv Estadual Maringa, Dept Physiol Sci, Maringa, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biomed Engn, Sao Jose Dos Campos, Brazil
dc.description.affiliationBoston Sch Med, Dept Biochem, Boston, MA USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biomed Engn, Sao Jose Dos Campos, Brazil
dc.description.sponsorshipIDFAPESP: 2010/51078-1
dc.description.sponsorshipIDFAPESP: 2008/54091-9
dc.description.sponsorshipIDFAPESP: 2012/51094-1
dc.description.sourceWeb of Science
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