Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38652
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMedeiros, Felipe A.
dc.contributor.authorGracitelli, Carolina P. B. [UNIFESP]
dc.contributor.authorBoer, Erwin R.
dc.contributor.authorWeinreb, Robert N.
dc.contributor.authorZangwill, Linda M.
dc.contributor.authorRosen, Peter N.
dc.date.accessioned2016-01-24T14:39:56Z-
dc.date.available2016-01-24T14:39:56Z-
dc.date.issued2015-02-01
dc.identifierhttp://dx.doi.org/10.1016/j.ophtha.2014.08.014
dc.identifier.citationOphthalmology. New York: Elsevier B.V., v. 122, n. 2, p. 293-301, 2015.
dc.identifier.issn0161-6420
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38652-
dc.description.abstractPurpose: To evaluate the association between longitudinal changes in quality of life (QoL) and rates of progressive visual field loss in glaucoma.Design: Prospective observational cohort study.Participants: We recruited 322 eyes of 161 patients with glaucomatous visual field loss from the Diagnostic Innovations Glaucoma Study followed for an average of 3.5 +/- 0.7 years.Methods: All subjects had National Eye Institute Visual Function Questionnaire (NEI VFQ)-25 performed annually and standard automated perimetry (SAP) at 6-month intervals. Subjects were included if they had a minimum of 2 NEI VFQ-25 and >= 5 SAP during follow-up. Evaluation of rates of visual field change was performed using the mean sensitivity (MS) of the integrated binocular visual field (BVF). Rasch analysis was performed to obtain final scores of disability as measured by the NEI VFQ-25. A joint longitudinal multivariate mixed model was used to investigate the association between change in NEI VFQ-25 Rasch-calibrated scores and change in BVF sensitivity. Potentially confounding socioeconomic and clinical variables also were analyzed.Main Outcome Measures: the relationship between change in NEI VFQ-25 Rasch-calibrated scores and change in binocular SAP MS.Results: There was a significant correlation between change in the NEI VFQ-25 Rasch scores during follow-up and change in binocular SAP sensitivity. Each 1-dB change in binocular SAP MS per year was associated with a change of 2.9 units per year in the NEI VFQ-25 Rasch scores during the follow-up period (R-2 = 26%; P<0.001). Eyes with more severe disease at baseline were also more likely to have a decrease in NEI VFQ-25 scores during follow-up (P<0.001). for subjects with the same amount of change in SAP sensitivity, those with shorter follow-up times had larger changes in NEI VFQ-25 scores (P = 0.005). A multivariable model containing baseline and rate of change in binocular MS had an adjusted R-2 of 50% in predicting change in NEI VFQ-25 scores.Conclusions: Baseline severity, magnitude, and rates of change in BVF sensitivity were associated with longitudinal changes in QoL of glaucoma patients. Assessment of longitudinal visual field changes may help to identify patients at greater risk for developing disability from the disease. (C) 2015 by the American Academy of Ophthalmology.en
dc.description.sponsorshipNational Institutes of Health/National Eye Institute
dc.description.sponsorshipResearch to Prevent Blindness (RPB)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAlcon
dc.description.sponsorshipAllergan
dc.description.sponsorshipPfizer
dc.description.sponsorshipMerck
dc.description.sponsorshipSanten
dc.description.sponsorshipCarl-Zeiss Meditec
dc.description.sponsorshipHeidelberg Engineering
dc.format.extent293-301
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofOphthalmology
dc.rightsAcesso aberto
dc.titleLongitudinal Changes in Quality of Life and Rates of Progressive Visual Field Loss in Glaucoma Patientsen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniv Calif San Diego
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Calif San Diego, Hamilton Glaucoma Ctr, La Jolla, CA 92093 USA
dc.description.affiliationUniv Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY021818
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY11008
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY14267
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY019869
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: P30EY022589
dc.description.sponsorshipIDCAPES: 12309-13-3
dc.identifier.doi10.1016/j.ophtha.2014.08.014
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000348290000021
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.