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Title: Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet
Authors: Moreno, Mayara Franzoi [UNIFESP]
Souza, Gabriel Inacio de Morais Honorato de [UNIFESP]
Hachul, Ana Claudia Losinskas [UNIFESP]
Santos, Bruno dos [UNIFESP]
Okuda, Marcos Hiromu [UNIFESP]
Pinto Neto, Nelson Inacio [UNIFESP]
Boldarine, Valter Tadeu [UNIFESP]
Esposito, Elisa [UNIFESP]
Ribeiro, Eliane Beraldi [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Ganen, Aline de Piano [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Mesenteric adipose tissue
Issue Date: 28-Mar-2014
Publisher: Biomed Central Ltd
Citation: Nutrition & Metabolism. London: Biomed Central Ltd, v. 11, 9 p., 2014.
Abstract: Background: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. the aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet.Methods: Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)].Results: the high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-kappa B p50. in HC we observed a positive correlation between IL-10 and TNF-alpha in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue.Conclusions: High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu.
ISSN: 1743-7075
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