Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37297
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dc.contributor.authorNovaes e Brito, Ronni Romulo [UNIFESP]
dc.contributor.authorXander, Patricia [UNIFESP]
dc.contributor.authorPerez, Elizabeth C. [UNIFESP]
dc.contributor.authorMaricato, Juliana Terzi [UNIFESP]
dc.contributor.authorLaurindo, Maria Fl. [UNIFESP]
dc.contributor.authorDe Lorenzo, Beatriz H. P. [UNIFESP]
dc.contributor.authorPellegrino, Renata [UNIFESP]
dc.contributor.authorBernardo, Viviane [UNIFESP]
dc.contributor.authorLopes, Jose Daniel [UNIFESP]
dc.contributor.authorMariano, Mario [UNIFESP]
dc.date.accessioned2016-01-24T14:35:07Z
dc.date.available2016-01-24T14:35:07Z
dc.date.issued2014-01-01
dc.identifierhttp://dx.doi.org/10.3109/08820139.2014.915413
dc.identifier.citationImmunological Investigations. London: Informa Healthcare, v. 43, n. 7, p. 675-692, 2014.
dc.identifier.issn0882-0139
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37297
dc.description.abstractNew Zealand Black X New Zealand White F1 [(NZB/NZW) F1] mice develop an autoimmune condition with similarities to human systemic lupus erythematosus (SLE). in this study, we demonstrate that B-1 cells, which have previously been reported to be involved in several autoimmune diseases, have altered gene expression in these mice. RNA was extracted from purified B-1 cells of disease-free C57BL/6 mice and lupus-prone (NZB/NZW) F1 mice. Gene expression was analysed using DNA microarray techniques and validated by real time reverse transcriptase polymerase chain reaction (RT-PCR). in (NZB/NZW) F1 mice, some genes had altered expression patterns compared to disease-free controls. Specifically, the upregulation of Ifitm1, Pvrl2 and Ifi202b and downregulation of Trp53bp1 mRNA were observed in (NZB/NZW) F1 mice. These genes are known to be associated with autoimmune diseases. This pattern of gene expression in B-1 cells could understanding of the pathogenesis of SLE. Thus, it is reasonable to hypothesise that the altered gene expression observed in B-1 cells in our experimental model is important for SLE prognosis and therapy, and these implications are discussed herein.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent675-692
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofImmunological Investigations
dc.rightsAcesso restrito
dc.subjectAutoimmunityen
dc.subjectB-1 cellsen
dc.subjectmicroarrayen
dc.subject(NZB/NZW) F1en
dc.subjectSLEen
dc.titleGene Expression in B-1 Cells from Lupus-Prone Miceen
dc.typeArtigo
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Univ Sao Camilo
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, Disciplina Imunol, São Paulo, Brazil
dc.description.affiliationCtr Univ Sao Camilo, BR-04262300 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Biol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Informat & Saude, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, Disciplina Imunol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Biol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Informat & Saude, São Paulo, Brazil
dc.identifier.doi10.3109/08820139.2014.915413
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000341303600006
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