Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37175
Title: Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil
Authors: Candida, Thamyris
Franca, Jeronimo Pereira de
Fonseca Chaves, Alba Lucilvania
Rodrigues Lopes, Fernanda Andrade
Gaiba, Silvana
Sacramento, Celio Kersul do
Ferreira, Lydia Masako [UNIFESP]
Franca, Lucimar Pereira de
Univ Estadual Santa Cruz UESC
Univ Estadual Santa Cruz
Universidade Federal de São Paulo (UNIFESP)
1A CNPq
Med III CAPES
Keywords: Morinda citrifolia L.
Morinda
Drug Screening Assays Antitumor
Anti-Infective Agents
Antimicrobial
Issue Date: 1-Jan-2014
Publisher: Acta Cirurgica Brasileira
Citation: Acta Cirurgica Brasileira. São Paulo: Acta Cirurgica Brasileira, v. 29, p. 10-14, 2014.
Abstract: PURPOSE: To evaluate the antitumor and antimicrobial activity of ethanolic extract of Morinda citrifolia L. fruit cultivated in southeastern Brazil.METHODS: Preparation ethanolic extract of the fruit of Morinda citrifolia L. Culture of melanoma cells B16-F10 for treatment with ethanolic extract of Morinda citrifolia L. fruit to determine cell viability by MTT and determination temporal effect of ethanolic extract fruit on the cell growth B16-F10 for 8 days. Evaluation of antimicrobial activity of ethanolic extract fruit against Staphylococcus aureus and Escherichia coli by determination of Minimum Inhibitory Concentration (MIC).RESULTS: the ethanolic extract of Morinda citrifolia L. fruit (10mg/mL) decreased cellular activity and inhibited 45% the rate of cell proliferation of B16-F10 melanoma treated during period studied. the ethanolic extract of Morinda citrifolia L. fruit demonstrated antimicrobial activity inhibiting the growth of both microorganisms studied. Staphylococcus aureus was less resistant to ethanolic extract of Morinda citrifolia L. fruit than Escherichia coli, 1 mg/mL and 10 mg/mL, respectively.CONCLUSION: What these results indicate that the ethanolic extract of the fruit of Morinda citrifolia L. showed antitumor activity with inhibition of viability and growth of B16-F10 cells and also showed antibacterial activity as induced inhibition of growth of Staphylococcus aureus and Escherichia coli.
URI: http://repositorio.unifesp.br/handle/11600/37175
ISSN: 0102-8650
Other Identifiers: http://dx.doi.org/10.1590/S0102-86502014001400003
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