Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/36735
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dc.contributor.authorAndrade Banzato, Priscilla Chamelete [UNIFESP]
dc.contributor.authorDaher, Silvia [UNIFESP]
dc.contributor.authorTraina, Evelyn [UNIFESP]
dc.contributor.authorTorloni, Maria Regina [UNIFESP]
dc.contributor.authorGueuvoghlanian-Silva, Barbara Yasmin [UNIFESP]
dc.contributor.authorPuccini, Renata Fiorini [UNIFESP]
dc.contributor.authorTezotto Pendeloski, Karen Priscilla [UNIFESP]
dc.contributor.authorMattar, Rosiane [UNIFESP]
dc.date.accessioned2016-01-24T14:34:23Z-
dc.date.available2016-01-24T14:34:23Z-
dc.date.issued2013-09-01
dc.identifierhttp://dx.doi.org/10.1177/1933719113477488
dc.identifier.citationReproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 20, n. 9, p. 1111-1115, 2013.
dc.identifier.issn1933-7191
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36735-
dc.description.abstractWe assessed FAS and FAS-L gene polymorphisms and messenger RNA (mRNA) levels in patients with recurrent pregnancy loss (RPL). This case-control study compared 129 women with RPL with 235 healthy multiparous women (control group). Genomic DNA and total mRNA were extracted from whole blood, and polymorphisms genotyping was performed by polymerase chain reaction (PCR). Messenger RNA expression levels were analyzed by real-time PCR. Data were analyzed by chi-square and Fisher exact tests; P < .05 was considered significant. There were no significant differences in the FAS (670 A/G) genotype or allelic frequencies between the RPL and control groups. We found significant differences in the FAS-L (844 C/T) genotype and allelic frequencies between women with RPL and controls. Patients with RPL had significantly higher FAS-L expression. Our data suggest that FAS-L gene polymorphism is associated with increased susceptibility to RPL. Moreover, women with RPL seem to abnormally express FAS-FAS-L molecules.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1111-1115
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofReproductive Sciences
dc.rightsAcesso restrito
dc.subjectrecurrent pregnancy lossen
dc.subjectpolymorphismen
dc.subjectFASen
dc.subjectFAS-Len
dc.subjectapoptosisen
dc.titleFAS and FAS-L Genotype and Expression in Patients With Recurrent Pregnancy Lossen
dc.typeArtigo
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet, BR-04037001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet, BR-04037001 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 09/50236-5
dc.description.sponsorshipIDCNPq: 301886/2009-1
dc.identifier.doi10.1177/1933719113477488
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000323180300015
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