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Title: Epidemiological assessment and therapeutic response in hypopharyngeal cancer
Other Titles: Avaliação epidemiológica e da resposta terapêutica no câncer da hipofaringe
Authors: Amar, Ali [UNIFESP]
Curioni, Otavio Alberto
Paiva, Diogenes Lopes de
Rapoport, Abrao
Dedivitis, Rogerio Aparecido
Cernea, Claudio Roberto
Brandao, Lenine Garcia
Universidade Federal de São Paulo (UNIFESP)
Heliopolis Hosp
Universidade de São Paulo (USP)
Sao Jose Hosp RBBP
Sao Jose Hosp
Keywords: epidemiology
hypopharyngeal neoplasms
neoplasm staging
squamous cell carcinoma
survival analysis
Issue Date: 1-Jul-2013
Publisher: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
Citation: Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 79, n. 4, p. 500-504, 2013.
Abstract: Despite the low incidence, diagnostic and therapeutic advances, hypopharyngeal cancer still has high mortality.Objective: To evaluate retrospectively the epidemiological profile and response to surgery and radiation/chemotherapy of patients with hypopharyngeal cancer.Method: We reviewed the medical records of 114 patients treated between 2002 and 2009 in a tertiary hospital with histopathological diagnosis of squamous cell carcinoma.Results: the mean age of the patients was 57 years, 94.7% were males and 5.3% females, 98.2% were smokers and 92% consumed alcohol; 72% are illiterate or did not complete first grade schooling. the main complaints were: neck node (28%), pain and dysphagia (22%), odynophagia (12.2%), dysphonia (7.8%). the clinical staging was: I (1.7%), II (3.5%), III (18.4%), IV (76.3%). the treatment was carried out with radiotherapy and chemotherapy alone in 35%, with mean 2-year survival of 20% and 5-year survival of 18%; surgery followed by radiotherapy and chemotherapy in 22.8% with 2-year survival of 60.0% and 5 years of 55.0%; chemotherapy alone in 2.6%, and 39.4% without treatment.Conclusion: Most patients already had advanced clinical stages and independent of the treatment option, had a low survival rate, confirming the poor prognosis of this neoplasm.
ISSN: 1808-8694
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