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Title: Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature
Authors: Gomes, Caio Perez [UNIFESP]
Torloni, Maria Regina [UNIFESP]
Gueuvoghlanian-Silva, Barbara Yasmin [UNIFESP]
Alexandre, Sandra Maria [UNIFESP]
Mattar, Rosiane [UNIFESP]
Daher, Silvia [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Blood specimen collection
gestational diabetes mellitus
Issue Date: 1-Jun-2013
Publisher: Wiley-Blackwell
Citation: American Journal of Reproductive Immunology. Hoboken: Wiley-Blackwell, v. 69, n. 6, p. 545-557, 2013.
Abstract: Problem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of Study Three electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. Results Twenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD=0.45, 95% CI 0.341.23). Conclusions New studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM.
ISSN: 1046-7408
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Appears in Collections:Em verificação - Geral

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