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dc.contributor.authorLisboa, Renato [UNIFESP]
dc.contributor.authorChun, Yeoun Sook
dc.contributor.authorZangwill, Linda M.
dc.contributor.authorWeinreb, Robert N.
dc.contributor.authorRosen, Peter N.
dc.contributor.authorLiebmann, Jeffrey M.
dc.contributor.authorGirkin, Christopher A.
dc.contributor.authorMedeiros, Felipe A.
dc.identifier.citationJama Ophthalmology. Chicago: Amer Medical Assoc, v. 131, n. 4, p. 486-494, 2013.
dc.description.abstractImportance: It is reasonable to hypothesize that for 2 patients with similar degrees of integrated binocular visual field (BVF) loss, the patient with a history of faster disease progression will report worse vision-related quality of life (VRQOL) than the patient with slowly progressing damage. However, to our knowledge, this hypothesis has not been investigated in the literature.Objective: To evaluate the association between binocular rates of visual field change and VRQOL in patients with glaucoma.Design: Observational cohort study.Setting: Patients were recruited from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study.Participants: the study included 796 eyes of 398 patients with diagnosed or suspected glaucoma followed up from October 1, 1998, until January 31, 2012, for a mean (SD) of 7.3(2.0) years.Main Outcome Measures: the VRQOL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) at the last follow-up visit. the NEI VFQ-25 was completed for all patients during the period extending from December 1, 2009, through January 31, 2012. Integrated BVFs were calculated from the monocular fields of each patient. Linear regression of mean deviation values was used to evaluate rates of BVF change during the follow-up period. Logistic regression models were used to investigate the association between abnormal VRQOL and rates of BVF change, while adjusting for potentially confounding socioeconomic and demographic variables.Results: Thirty-two patients (8.0%) had abnormal VRQOL as determined by the results of the NEI VFQ-25. Patients with abnormal VRQOL had significantly faster rates of BVF change than those with normal VRQOL (-0.18 vs -0.06 dB/y; P<.001). Rates of BVF change were significantly associated with abnormality in VRQOL (odds ratio=1.31 per 0.1 dB/y faster; P=.04), after adjustment for confounding variables.Conclusions and Relevance: Patients with faster rates of BVF change were at higher risk of reporting abnormal VRQOL. Assessment of rates of BVF change may provide useful information in determining risk of functional impairment in glaucoma.en
dc.description.sponsorshipNational Institutes of Health/National Eye Institute
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipResearch to Prevent Blindness
dc.description.sponsorshipAlcon Laboratories, Inc
dc.description.sponsorshipAllergan, Inc
dc.description.sponsorshipPfizer, Inc
dc.description.sponsorshipMerck, Inc
dc.description.sponsorshipSanten, Inc
dc.publisherAmer Medical Assoc
dc.relation.ispartofJama Ophthalmology
dc.rightsAcesso aberto
dc.titleAssociation Between Rates of Binocular Visual Field Loss and Vision-Related Quality of Life in Patients With Glaucomaen
dc.contributor.institutionUniv Calif San Diego
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionChung Ang Univ
dc.contributor.institutionNew York Eye & Ear Infirm
dc.contributor.institutionUniv Alabama Birmingham
dc.description.affiliationUniv Calif San Diego, Hamilton Glaucoma Ctr, San Diego, CA 92103 USA
dc.description.affiliationUniv Calif San Diego, Dept Ophthalmol, San Diego, CA 92103 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationChung Ang Univ, Coll Med, Dept Ophthalmol, Seoul 156756, South Korea
dc.description.affiliationNew York Eye & Ear Infirm, Dept Ophthalmol, New York, NY 10003 USA
dc.description.affiliationUniv Alabama Birmingham, Dept Ophthalmol, Birmingham, AL 35294 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY021818
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY11008
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY14267
dc.description.sponsorshipIDCAPES: BEX 1066/11-0
dc.description.sourceWeb of Science
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