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Title: Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH
Authors: da-Rosa, Dayane D.
Valvassori, Samira S.
Steckert, Amanda V.
Ornell, Felipe
Ferreira, Camila L.
Lopes-Borges, Jessica
Varela, Roger B.
Dal-Pizzol, Felipe
Andersen, Monica L. [UNIFESP]
Quevedo, Joao
Univ So Santa Catarina
Universidade Federal de São Paulo (UNIFESP)
Keywords: Animal model of mania
Oxidative stress
Issue Date: 15-Aug-2012
Publisher: Elsevier B.V.
Citation: Psychiatry Research. Clare: Elsevier B.V., v. 198, n. 3, p. 521-526, 2012.
Abstract: In the last years our research group has studied and validated the animal model of mania induced by dextroamphetamine (D-AMPH). Considering the lack of animal models of mania reported in the literature; this study evaluated the possibilities to validate the animal model induced by methamphetamine (m-AMPH). Then, we evaluated the effects of lithium (Li), valproate (VPA) on the behavior and parameters of oxidative damage in rat brain after administration of m-AMPH. in the prevention treatment, Wistar rats were pretreated with Li. VPA or saline (Sal) for 14 days, and then, between days 8 and 14, rats were treated with m-AMPH (1, 0.5 or 0.25 mg/kg) or Sal. in the reversal treatment, rats were first given m-AMPH (0.25 mg/kg) or Sal. Locomotor behavior was assessed using the open-field task and parameters of oxidative damage were measured in brain structures. Our results show that the hyperactivity was prevented and reverted by Li and VPA only when m-AMPH was administered in the dose of 0.25 mg/kg. in addition, the m-AMPH in all doses administrated induced oxidative damage in both structures tested in two models. Li and VPA reversed and prevented this impairment, however in a way dependent of cerebral area, the dose of m-AMPH and technique. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0165-1781
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