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dc.contributor.authorPrata, Tiago Santos [UNIFESP]
dc.contributor.authorLima, Veronica C. [UNIFESP]
dc.contributor.authorDe Moraes, Carlos Gustavo V.
dc.contributor.authorTrubnik, Valerie
dc.contributor.authorDerr, Peter
dc.contributor.authorLiebmann, Jeffrey M.
dc.contributor.authorRitch, Robert
dc.contributor.authorTello, Celso
dc.identifier.citationJournal of Glaucoma. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 6, p. 415-420, 2012.
dc.description.abstractPurpose: To investigate the correlation between structural and functional damage in patients with asymmetric glaucoma using a newly developed short duration transient visual evoked potential (SD-tVEP) device.Methods: Twenty-five patients with visual acuity >= 20/30 and asymmetric visual field (VF) loss [inter-eye difference in mean deviation index (MD) of at least 3 dB] were enrolled. Patients underwent optical coherence tomography (OCT) for macular thickness measurement, scanning laser polarimetry with variable corneal compensation for retinal nerve fiber layer measurement, and SD-tVEP (10% and 85% Michelson contrast, acquisition time of 20 s) in both eyes within 2 months. We correlated VF MD and structural test results with SD-tVEP P100 latency and Delta Amplitude (N75-P100).Results: Using 10% contrast, there was a significant difference in SD-tVEP latency and amplitude between eyes with better and worse VF MD (P < 0.001). MD correlated significantly with both SD-tVEP parameters (r > 0.33, P <= 0.01). When using 85% contrast, SD-tVEP amplitude differed between eyes (P = 0.01) and MD values correlated significantly with amplitude results (r = 0.32, P = 0.01), but not with latency (P = 0.46). in eyes with more advanced VF loss, there was a positive and significant correlation between SD-tVEP amplitude (85% contrast) and macular thickness on OCT (r = 0.47, P = 0.01), but not with retinal nerve fiber layer measured with polarimetry (P = 0.26).Conclusions: in cases of asymmetric glaucoma, SD-tVEP results correlate significantly with the level of VF damage as measured by MD. in the eyes with more advanced VF loss, reduced SD-tVEP amplitude was associated with decreased macular thickness on OCT. These findings suggest that SD-tVEP may be a fast and objective method to assess or screen for functional damage in glaucomatous eyes.en
dc.description.sponsorshipDiopsys, Inc
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Glaucoma
dc.rightsAcesso aberto
dc.subjectvisual evoked potentialen
dc.subjectoptical coherence tomographyen
dc.subjectscanning laser polarimetryen
dc.titleShort Duration Transient Visual Evoked Potentials in Glaucomatous Eyesen
dc.contributor.institutionNew York Eye & Ear Infirm
dc.contributor.institutionNew York Med Coll
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionDiopsys Inc
dc.description.affiliationNew York Eye & Ear Infirm, Dept Ophthalmol, Einhorn Clin Res Ctr, New York, NY 10003 USA
dc.description.affiliationNYU, Dept Ophthalmol, Sch Med, New York, NY 10016 USA
dc.description.affiliationNew York Med Coll, Dept Ophthalmol, Valhalla, NY 10595 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationDiopsys Inc, Pine Brook, NJ USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
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