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Title: Short Duration Transient Visual Evoked Potentials in Glaucomatous Eyes
Authors: Prata, Tiago Santos [UNIFESP]
Lima, Veronica C. [UNIFESP]
De Moraes, Carlos Gustavo V.
Trubnik, Valerie
Derr, Peter
Liebmann, Jeffrey M.
Ritch, Robert
Tello, Celso
New York Eye & Ear Infirm
New York Med Coll
Universidade Federal de São Paulo (UNIFESP)
Diopsys Inc
Keywords: glaucoma
visual evoked potential
optical coherence tomography
scanning laser polarimetry
Issue Date: 1-Aug-2012
Publisher: Lippincott Williams & Wilkins
Citation: Journal of Glaucoma. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 6, p. 415-420, 2012.
Abstract: Purpose: To investigate the correlation between structural and functional damage in patients with asymmetric glaucoma using a newly developed short duration transient visual evoked potential (SD-tVEP) device.Methods: Twenty-five patients with visual acuity >= 20/30 and asymmetric visual field (VF) loss [inter-eye difference in mean deviation index (MD) of at least 3 dB] were enrolled. Patients underwent optical coherence tomography (OCT) for macular thickness measurement, scanning laser polarimetry with variable corneal compensation for retinal nerve fiber layer measurement, and SD-tVEP (10% and 85% Michelson contrast, acquisition time of 20 s) in both eyes within 2 months. We correlated VF MD and structural test results with SD-tVEP P100 latency and Delta Amplitude (N75-P100).Results: Using 10% contrast, there was a significant difference in SD-tVEP latency and amplitude between eyes with better and worse VF MD (P < 0.001). MD correlated significantly with both SD-tVEP parameters (r > 0.33, P <= 0.01). When using 85% contrast, SD-tVEP amplitude differed between eyes (P = 0.01) and MD values correlated significantly with amplitude results (r = 0.32, P = 0.01), but not with latency (P = 0.46). in eyes with more advanced VF loss, there was a positive and significant correlation between SD-tVEP amplitude (85% contrast) and macular thickness on OCT (r = 0.47, P = 0.01), but not with retinal nerve fiber layer measured with polarimetry (P = 0.26).Conclusions: in cases of asymmetric glaucoma, SD-tVEP results correlate significantly with the level of VF damage as measured by MD. in the eyes with more advanced VF loss, reduced SD-tVEP amplitude was associated with decreased macular thickness on OCT. These findings suggest that SD-tVEP may be a fast and objective method to assess or screen for functional damage in glaucomatous eyes.
ISSN: 1057-0829
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