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Title: Paradoxical sleep deprivation induces muscle atrophy
Authors: Dattilo, Murilo [UNIFESP]
Antunes, Hanna Karen Moreira [UNIFESP]
Medeiros, Alessandra [UNIFESP]
Mônico-Neto, Marcos [UNIFESP]
Souza, Helton de Sá
Lee, Kil Sun [UNIFESP]
Tufik, Sergio [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: cross-sectional area
muscle atrophy
paradoxical sleep deprivation
Issue Date: 1-Mar-2012
Publisher: Wiley-Blackwell
Citation: Muscle & Nerve. Malden: Wiley-Blackwell, v. 45, n. 3, p. 431-433, 2012.
Abstract: Introduction: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleepdeprived rats.Methods: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. Results: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. the 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. Conclusion: PSD induces hormonal alterations that may mediate muscle atrophy. Muscle Nerve, 2012
ISSN: 0148-639X
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