Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/34539
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dc.contributor.authorCassilhas, Ricardo Cardoso [UNIFESP]
dc.contributor.authorLee, Kil Sun [UNIFESP]
dc.contributor.authorFernandes, Jansen [UNIFESP]
dc.contributor.authorOliveira, Maria Gabriela Menezes de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMeeusen, R.
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.date.accessioned2016-01-24T14:17:49Z
dc.date.available2016-01-24T14:17:49Z
dc.date.issued2012-01-27
dc.identifierhttps://dx.doi.org/10.1016/j.neuroscience.2011.11.029
dc.identifier.citationNeuroscience. Oxford: Pergamon-Elsevier B.V., v. 202, p. 309-317, 2012.
dc.identifier.issn0306-4522
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/34539
dc.description.abstractA growing body of scientific evidence indicates that exercise has a positive impact on human health, including neurological health. Aerobic exercise, which is supposed to enhance cardiovascular functions and metabolism, also induces neurotrophic factors that affect hippocampal neurons, thereby improving spatial learning and memory. Alternatively, little is known about the effect of resistance exercise on hippocampus-dependent memory, although this type of exercise is increasingly recommended to improve muscle strength and bone density and to prevent age-related disabilities. Therefore, we evaluated the effects of resistance training on spatial memory and the signaling pathways of brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1), comparing these effects with those of aerobic exercise. Adult male Wistar rats underwent 8 weeks of aerobic training on a treadmill (AERO group) or resistance training on a vertical ladder (RES group). Control and sham groups were also included. After the training period, both AERO and RES groups showed improved learning and spatial memory in a similar manner. However, both groups presented distinct signaling pathways. Although the AERO group showed increased level of IGF-1, BDNF, TrkB, and g-CaMKII (calcium/calmodulin-dependent kinase II) in the hippocampus, the RES group showed an induction of peripheral and hippocampal IGF-1 with concomitant activation of receptor for IGF-1 (IGF-1R) and AKT in the hippocampus. These distinct pathways culminated in an increase of synapsin 1 and synaptophysin expression in both groups. These findings demonstrated that both aerobic and resistance exercise can employ divergent molecular mechanisms but achieve similar results on learning and spatial memory. (C) 2011 IBRO. Published by Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipResearch Incentive Fund Association (AFIP)
dc.description.sponsorshipPsychobiology and Exercise Research Center (CEPE)
dc.description.sponsorshipMultidisciplinary Center for the Study of Drowsiness and Accidents (CEMSA)
dc.description.sponsorshipResearch Innovation and Dissemination Centers-SLEEP (CEPID-Sleep)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent309-317
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience
dc.rightsAcesso restrito
dc.subjectSpatial learningen
dc.subjectMemoryen
dc.subjectHippocampusen
dc.subjectPhysical exerciseen
dc.subjectWater mazeen
dc.titleSpatial memory is improved by aerobic and resistance exercise through divergent molecular mechanismsen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCEPE
dc.contributor.institutionVrije Univ Brussel
dc.description.affiliationUNIFESP Universidade Federal de São Paulo, Dept Psychobiol, CEPE Psychobiol & Exercise Res Ctr, BR-04020050 São Paulo, Brazil
dc.description.affiliationCEPE, Psychobiol & Exercise Res Ctr, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurophysiol, UNIFESP, São Paulo, Brazil
dc.description.affiliationVrije Univ Brussel, Dept Human Physiol & Sports Med, Brussels, Belgium
dc.description.affiliationUnifespUNIFESP Universidade Federal de São Paulo, Dept Psychobiol, CEPE Psychobiol & Exercise Res Ctr, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurophysiol, UNIFESP, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2008/03083-6
dc.identifier.doi10.1016/j.neuroscience.2011.11.029
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000299908000029
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