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Title: Metabolic impact of shift work
Authors: Zimberg, Iona Zalcman [UNIFESP]
Fernandes Junior, Silvio A.
Crispim, Cibele Aparecida [UNIFESP]
Tufik, Sergio [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Ctr Estudo Multidisciplinar Sonolencia & Acidente
Universidade Federal de Uberlândia (UFU)
Keywords: Shift work
sleep restriction
circadian misalignment
Issue Date: 1-Jan-2012
Publisher: Ios Press
Citation: Work-a Journal of Prevention Assessment & Rehabilitation. Amsterdam: Ios Press, v. 41, p. 4376-4383, 2012.
Abstract: In developing countries, shift work represents a considerable contingent workforce. Recently, studies have shown that overweight and obesity are more prevalent in shift workers than day workers. in addition, shift work has been associated with a higher propensity for the development of many metabolic disorders, such as insulin resistance, diabetes, dislipidemias and metabolic syndrome. Recent data have pointed that decrease of the sleep time, desynchronization of circadian rhythm and alteration of environmental aspects are the main factors related to such problems. Shortened or disturbed sleep is among the most common health-related effects of shift work. the plausible physiological and biological mechanisms are related to the activation of the autonomic nervous system, inflammation, changes in lipid and glucose metabolism, and related changes in the risk for atherosclerosis, metabolic syndrome, and type II diabetes. the present review will discuss the impact of shift work on obesity and metabolic disorders and how disruption of sleep and circadian misalignment may contribute to these metabolic dysfunctions.
ISSN: 1051-9815
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