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Title: Differences between dextroamphetamine and methamphetamine: behavioral changes and oxidative damage in brain of Wistar rats
Authors: da-Rosa, Dayane D.
Valvassori, Samira S.
Steckert, Amanda V.
Arent, Camila O.
Ferreira, Camila L.
Lopes-Borges, Jessica
Varela, Roger B.
Mariot, Edemilson
Dal-Pizzol, Felipe
Andersen, Monica L. [UNIFESP]
Quevedo, Joao
Univ Extremo Catarinense
Univ So Santa Catarina
Universidade Federal de São Paulo (UNIFESP)
Keywords: Dextroamphetamine
Oxidative damage
Locomotor activity
Exploratory activity
Issue Date: 1-Jan-2012
Publisher: Springer
Citation: Journal of Neural Transmission. Wien: Springer Wien, v. 119, n. 1, p. 31-38, 2012.
Abstract: In this study methamphetamine (m-AMPH) and dextroamphetamine (d-AMPH) were compared to determine the potency of the two drugs on behavior and oxidative damage in brain of rats. Male adult Wistar rats were given single (acute administration) or repeated (chronic administration, 14 days) intraperitoneal injections of saline (0.9% NaCl), d-AMPH (2 mg/kg) or m-AMPH (0.25, 0.5, 1 or 2 mg/kg). Locomotor activity was evaluated in open-field apparatus 2 h after the last drug injection. Additionally, thiobarbituric acid reactive substances (TBARS) and protein carbonyl formation were measured in the prefrontal cortex, amygdala, hippocampus and striatum. in both experiments, d-AMPH and m-AMPH (all doses administered) increased the locomotor activity of animals, meantime, no significant difference between d-AMPH and m-AMPH was observed. d-AMPH and m-AMPH increased lipid and protein damage, but m-AMPH was more potent than d-AMPH, however, this effect varies depending on the brain region and the experimental protocol. the results of this study show that d-AMPH and m-AMPH have similar behavioral effects, which previous studies had already reported. On the other hand, this study demonstrated that the m-AMPH induces oxidative damage greater than d-AMPH, showing neurochemical differences previously unknown.
ISSN: 0300-9564
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