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dc.contributor.authorLuz, Gabrielle da
dc.contributor.authorFrederico, Marisa J. S.
dc.contributor.authorSilva, Sabrina da
dc.contributor.authorVitto, Marcelo F.
dc.contributor.authorCesconetto, Patricia A.
dc.contributor.authorPinho, Ricardo A. de
dc.contributor.authorPauli, Jose R. [UNIFESP]
dc.contributor.authorSilva, Adelino S. R.
dc.contributor.authorCintra, Dennys E.
dc.contributor.authorRopelle, Eduardo R.
dc.contributor.authorDe Souza, Claudio T.
dc.identifier.citationEuropean Journal of Applied Physiology. New York: Springer, v. 111, n. 9, p. 2015-2023, 2011.
dc.description.abstractObesity-induced endoplasmatic reticulum (ER) stress has been demonstrated to underlie the induction of obesity-induced JNK and NF-kappa B activation inflammatory responses, and generation of peripheral insulin resistance. On the other hand, exercise has been used as a crucial tool in obese and diabetic patients, and may reduce inflammatory pathway stimulation. However, the ability of exercise training to reverse endoplasmatic reticulum stress in adipose and hepatic tissue in obesity has not been investigated in the literature. Here, we demonstrate that exercise training ameliorates ER stress and insulin resistance in DIO-induced rats. Rats were fed with standard rodent chow (3,948 kcal kg(-1)) or high-fat diet (5,358 kcal kg(-1)) for 2 months. After that rats were submitted to swimming training (1 h per day, 5 days for week with 5% overload of the body weight for 8 weeks). Samples from epididymal fat and liver were obtained and western blot analysis was performed. Our results showed that swimming protocol reduces pro-inflammatory molecules (JNK, I kappa B and NF-kappa B) in adipose and hepatic tissues. in addition, exercise leads to reduction in ER stress, by reducing PERK and eIF2 alpha phosphorylation in these tissues. in parallel, an increase in insulin pathway signaling was observed, as confirmed by increases in IR, IRSs and Akt phosphorylation following exercise training in DIO rats. Thus, results suggest that exercise can reduce ER stress, improving insulin resistance in adipose and hepatic tissue.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.relation.ispartofEuropean Journal of Applied Physiology
dc.rightsAcesso restrito
dc.subjectER stressen
dc.subjectInsulin resistanceen
dc.subjectExercise trainingen
dc.subjectInflammatory pathwayen
dc.titleEndurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese ratsen
dc.contributor.institutionUniv Extremo Catarinense
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.description.affiliationUniv Extremo Catarinense, Lab Fisiol & Bioquim Exercicio, Programa Posgrad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Sch Phys Educ, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Fac Sci Appl, Limeira, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Sch Phys Educ, Dept Biosci, Santos, SP, Brazil
dc.description.sourceWeb of Science
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