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dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.authorYamashita, Alex S.
dc.contributor.authorRosa Neto, José Cesar [UNIFESP]
dc.contributor.authorTavares, Fabio L.
dc.contributor.authorCaperuto, Erico
dc.contributor.authorCarnevali, Luiz C.
dc.contributor.authorPimentel, Gustavo Duarte [UNIFESP]
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.authorBatista, Miguel L.
dc.contributor.authorLaviano, Alessandro
dc.contributor.authorRossi-Fanelli, Filippo
dc.contributor.authorSeelaender, Marilia
dc.identifier.citationNutrition & Metabolism. London: Biomed Central Ltd, v. 8, 7 p., 2011.
dc.description.abstractAim: We tested the effects of a cancer cachexia-anorexia sydrome upon the balance of anti and pro-inflammatory cytokines in the hypothalamus of sedentary or trained tumour-bearing (Walker-256 carcinosarcoma) rats.Methods: Animals were randomly assigned to a sedentary control (SC), sedentary tumour-bearing (ST), and sedentary pair-fed (SPF) groups or, exercised control (EC), exercised tumour-bearing (ET) and exercised pair-fed (EPF) groups. Trained rats ran on a treadmill (60%VO(2max)) for 60 min/d, 5 days/wk, for 8 wks. We evaluated food intake, leptin and cytokine (TNF-alpha, IL1 beta) levels in the hypothalamus.Results: the cumulative food intake and serum leptin concentration were reduced in ST compared to SC. Leptin gene expression in the retroperitoneal adipose tissue (RPAT) was increased in SPF in comparison with SC and ST, and in the mesenteric adipose tissue (MEAT) the same parameter was decreased in ST in relation to SC. Leptin levels in RPAT and MEAT were decreased in ST, when compared with SC. Exercise training was also able to reduce tumour weight when compared to ST group. in the hypothalamus, IL-1 beta and IL-10 gene expression was higher in ST than in SC and SPF. Cytokine concentration in hypothalamus was higher in ST (TNF-alpha and IL-1 beta, p < 0.05), compared with SC and SPF. These pro-inflammatory cytokines concentrations were restored to control values (p < 0.05), when the animals were submitted to endurance training.Conclusion: Cancer-induced anorexia leads towards a pro-inflammatory state in the hypothalamus, which is prevented by endurance training which induces an anti-inflammatory state, with concomitant decrease of tumour weight.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherBiomed Central Ltd
dc.relation.ispartofNutrition & Metabolism
dc.rightsAcesso aberto
dc.subjectCancer cachexiaen
dc.subjectExercise trainingen
dc.titleHypothalamic inflammation is reversed by endurance training in anorectic-cachectic ratsen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSapienza Univ Rome
dc.description.affiliationUniv São Paulo USP, Inst Biomed Sci, Canc Metab Res Grp, São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Physiol, Div Nutr Physiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationSapienza Univ Rome, Dept Clin Med, Rome, Italy
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Physiol, Div Nutr Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 04/11588-0
dc.description.sponsorshipIDFAPESP: 05/01445-0
dc.description.sourceWeb of Science
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