Please use this identifier to cite or link to this item:
|Title:||In vivo infection by Trypanosoma cruzi: the conserved FLY domain of the gp85/trans-sialidase family potentiates host infection|
|Authors:||Tonelli, Renata Rosito [UNIFESP]|
Torrecilhas, Ana Claudia Trocoli
Jacysyn, J. F.
Juliano, Maria Aparecida [UNIFESP]
Alves, Maria Julia Manso
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
CD4(+)CD25(+)FoxP3(+) T cells
gp85/trans-sialidase glycoprotein family
|Publisher:||Cambridge Univ Press|
|Citation:||Parasitology. New York: Cambridge Univ Press, v. 138, n. 4, p. 481-492, 2011.|
|Abstract:||Trypanosoma cruzi is a protozoan parasite that infects vertebrates, causing in humans a pathological condition known as Chagas' disease. the infection of host cells by T. cruzi involves a vast collection of molecules, including a family of 85 kDa GPI-anchored glycoproteins belonging to the gp85/trans-sialidase superfamily, which contains a conserved cell-binding sequence (VTVXNVFLYNR) known as FLY, for short. Herein, it is shown that BALB/c mice administered with a single dose (1 mu g/animal, intraperitoneally) of FLY-synthetic peptide are more susceptible to infection by T. cruzi, with increased systemic parasitaemia (2-fold) and mortality. Higher tissue parasitism was observed in bladder (7.6-fold), heart (3-fold) and small intestine (3.6-fold). Moreover, an intense inflammatory response and increment of CD4(+) T cells (1.7-fold) were detected in the heart of FLY-primed and infected animals, with a 5-fold relative increase of CD4(+)CD25(+)FoxP3(+) T (Treg) cells. Mice treated with anti-CD25 antibodies prior to infection, showed a decrease in parasitaemia in the FLY model employed. in conclusion, the results suggest that FLY facilitates in vivo infection by T. cruzi and concurs with other factors to improve parasite survival to such an extent that might influence the progression of pathology in Chagas' disease.|
|Appears in Collections:||Em verificação - Geral|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.