Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33314
Title: The soybean concentrated extract proliferates the vagina of adult rats
Authors: Ferraz Carbonel, Adriana Aparecida [UNIFESP]
Pinheiro Baracat, Maria Candida [UNIFESP]
Simoes, Ricardo Santos
Simoes, Manuel Jesus [UNIFESP]
Baracat, Edmund Chada
Soares, Jose Maria [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Soy extract
Isoflavones
Conjugated estrogens
Vagina
Collagen
Rat
Issue Date: 1-Jan-2011
Publisher: Lippincott Williams & Wilkins
Citation: Menopause-the Journal of the North American Menopause Society. Philadelphia: Lippincott Williams & Wilkins, v. 18, n. 1, p. 93-101, 2011.
Abstract: Objective: the aim of this study was to evaluate changes induced on the vagina of ovariectomized rats after treatment with soybean concentrated extract or conjugated equine estrogens and the association of both drugs.Methods: We conducted an experimental study with 50 ovariectomized rats that were randomly divided into five equal groups of 10 animals: GI received vehicle, GII received soybean concentrated extract 46 mg/kg per day, GIII received soybean concentrated extract 120 mg/kg per day, GIV received conjugated equine estrogens 50 mu g/kg per day, and GV received conjugated equine estrogens 50 mu g/kg and soybean concentrated extract 46 mg/kg per day. the substances were administered by gavage during 21 consecutive days. After that, the animals were killed under anesthesia and the vagina was removed for histological and immunohistochemical analysis. Data were initially submitted to analysis of variance. Whenever a significant difference was detected, the study was complemented with the Tukey-Kramer test for multiple comparisons.Results: GII did not show any differences on the vaginal epithelium or collagen compared with GI. GIII presented an increase in vaginal epithelium and collagen amount. GIV had the highest amount of collagen and the signals of vaginal proliferation. GV did not show any additional effect compared with GIV.Conclusions: Our data suggest that a high dose of isoflavone-rich soy extract may have positive effects on the vaginal structures of ovariectomized rats, but this action is less than that of estrogen treatment on vaginal thickness. in addition, soy extract may not block the estrogen effect on vaginal tissue.
URI: http://repositorio.unifesp.br/handle/11600/33314
ISSN: 1072-3714
Other Identifiers: http://dx.doi.org/10.1097/gme.0b013e3181e5ee25
Appears in Collections:Em verificação - Geral

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