Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33012
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dc.contributor.authorLima, Veronica Castro [UNIFESP]
dc.contributor.authorRosen, Richard B.
dc.contributor.authorMaia, Mauricio [UNIFESP]
dc.contributor.authorPrata, Tiago Santos [UNIFESP]
dc.contributor.authorDorairaj, Syril
dc.contributor.authorFarah, Michel Eid [UNIFESP]
dc.contributor.authorSallum, Juliana [UNIFESP]
dc.date.accessioned2016-01-24T14:05:36Z-
dc.date.available2016-01-24T14:05:36Z-
dc.date.issued2010-11-01
dc.identifierhttp://dx.doi.org/10.1167/iovs.09-4695
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville: Assoc Research Vision Ophthalmology Inc, v. 51, n. 11, p. 5840-5845, 2010.
dc.identifier.issn0146-0404
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33012-
dc.description.abstractPURPOSE. To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dual-wavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels.METHODS. Forty-three patients were divided into groups 1 (controls, n = 14), 2 (diabetic without retinopathy, n = 17), and 3 (diabetic with mild nonproliferative retinopathy, n = 12). MPOD was measured with a modified confocal scanning laser ophthalmoscope and compared among groups (analysis of variance). the correlation of HbA1C and serum lipid (HDL, LDL, total cholesterol, and triglycerides) levels with MPOD was determined for each group (linear regression analysis).RESULTS. Mean +/- SD ages in groups 1 (56.2 +/- 11.7 years), 2 (58.6 +/- 11.5 years), and 3 (62.8 +/- 9.8 years) were similar (P = 0.324). Mean MPOD averaged in a 2 degrees-diameter circle around the fovea was significantly different between the three groups: 1, (0.29 +/- 0.07 density units [DU]), 2 (0.22 +/- 0.09 DU), and 3 (0.14 +/- 0.05 DU) (P < 0.001). There was a significant difference in mean MPOD levels at 0.5 degrees between groups 1 (0.51 +/- 0.12 DU) and 2 (0.24 +/- 0.11 DU; P < 0.001), but not between groups 2 and 3 (0.33 +/- 0.15 DU; P > 0.05). A significant inverse correlation was observed between HbA1C levels and mean MPOD, averaged at 2 around the fovea in all patients (r = -0.63, P < 0.001). No significant correlations were found between MPOD and serum lipid levels or age.CONCLUSIONS. Type 2 diabetic patients, with or without retinopathy, had reduced MPOD when compared with that in nondiabetic patients. in addition, a significant inverse correlation between MPOD and HbA1C levels was observed. (Invest Ophthalmol Vis Sci. 2010;51:5840-5845) DOI:10.1167/iovs.09-4695en
dc.format.extent5840-5845
dc.language.isoeng
dc.publisherAssoc Research Vision Ophthalmology Inc
dc.relation.ispartofInvestigative Ophthalmology & Visual Science
dc.rightsAcesso aberto
dc.titleMacular Pigment Optical Density Measured by Dual-Wavelength Autofluorescence Imaging in Diabetic and Nondiabetic Patients: A Comparative Studyen
dc.typeArtigo
dc.contributor.institutionNew York Eye & Ear Infirm
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionNew York Med Coll
dc.description.affiliationNew York Eye & Ear Infirm, Dept Ophthalmol, Retina Serv, New York, NY 10003 USA
dc.description.affiliationNew York Eye & Ear Infirm, Einhorn Clin Res Ctr, New York, NY 10003 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationNew York Med Coll, Dept Ophthalmol, New York, NY USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.identifier.doi10.1167/iovs.09-4695
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000283558400056
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