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Title: High-resolution computed tomography findings from adult patients with Influenza A (H1N1) virus-associated pneumonia
Authors: Marchiori, Edson
Zanetti, Glaucia
Hochhegger, Bruno
Rodrigues, Rosana Souza
Pantaleao Fontes, Cristina Asvolinsque
Nobre, Luiz Felipe
Mancano, Alexandre Dias
Meirelles, Gustavo [UNIFESP]
Irion, Klaus Loureiro
Universidade Federal Fluminense (UFF)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de Santa Catarina (UFSC)
Anchieta Hosp
Universidade Federal de São Paulo (UNIFESP)
Liverpool Heart & Chest Hosp NHS Trust
Royal Liverpool & Broadgreen Univ Hosp NHS
DOR Inst Res & Educ
Keywords: High-resolution computed tomography
Influenza A
H1N1 virus
Viral pneumonia
Issue Date: 1-Apr-2010
Publisher: Elsevier B.V.
Citation: European Journal of Radiology. Clare: Elsevier B.V., v. 74, n. 1, p. 93-98, 2010.
Abstract: Objective: the aim of this study was to assess the high-resolution computed tomography (HRCT) findings at presentation in patients diagnosed with Influenza A (H1N1) virus-associated pneumonia.Materials and methods: We reviewed the HRCT findings from 20 patients diagnosed with Influenza A (H1N1) and compared their HRCT scans with chest radiographs, obtained on the same day. the imaging studies were obtained 4-9 days after the onset of symptoms. the patients included 11 men and 9 women (ages 24-62 years; mean 42.7 years). All patients had a body temperature greater than 100.4 degrees F (> 38 degrees C), tachypnea, and cough. Other common symptoms included diarrhea (60%) and sore throat (30%). the radiographs and HRCT scans were reviewed independently by two observers who reached a consensus decision.Results: the predominant HRCT findings consisted of bilateral ground-glass opacities (n = 12), bilateral areas of consolidation (n = 2), or a mixed bilateral pattern of ground-glass opacities and areas of consolidation (n = 6). the abnormalities were bilateral in all of the 20 patients, had a predominantly sub-pleural distribution in 13 patients, and had a random distribution in the remaining 7 patients. the predominant radiographic findings were consolidations. Normal radiographs were found in 4 out of the 20 patients.Conclusion: HRCT may reveal parenchymal abnormalities in patients with Influenza A (H1N1) infection who have normal findings on radiographs. the predominant HRCT findings were bilateral, peripheral, ground-glass opacities and/or bilateral areas of consolidation. the patients who presented consolidations had more severe clinical course. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0720-048X
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